In vitro release behavior and cytotoxicity of doxorubicin-loaded gold nanoparticles in cancerous cells

Biotechnology Letters
B AsadishadI Alamzadeh

Abstract

Doxorubicin (DOX), a common cancer chemotherapeutics, was conjugated to folate-modified thiolated-polyethylene glycol-functionalized gold nanoparticles. The in vitro, controlled release behavior of DOX-loaded gold nanoparticles was observed using porous dialysis membranes (cut-off = 2 kDa). DOX-loaded gold nanoparticles had higher cytotoxicity for folate-receptor-positive cells (KB cells) compared to folate-receptor-negative cells (A549 cells) which were 48 and 62% viable for 10 microM doxorubicin, respectively. This indicates the potential of these nano-carriers for targeted-delivery. In addition, healthy cell viability was 69% for 10 microM free doxorubicin whereas for the same content of drug in DOX-loaded nanoparticles healthy cell viability increased to 80%.

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Citations

Aug 24, 2012·International Journal of Nanomedicine·Dhiraj KumarDorian Dixon
Jun 21, 2011·Journal of Pharmacy & Bioallied Sciences·K Sathish KumarS Vijayalakshmi
Nov 8, 2011·Therapeutic Delivery·Brian E O'Neill, Natalya Rapoport
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Sep 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Valerio VolianiFabio Beltram

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