In vitro release of hydrophobic drugs by oleogel rods with biocompatible gelators.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Russell MacoonAnuj Chauhan

Abstract

Currently, invasive monthly intravitreal injections through the eyeball are required to deliver retinal drugs. Injections of oleogels into the vitreous have the potential for extended release of both hydrophobic and hydrophilic drugs for extended durations which could decrease the frequency of injections. The type of gelator used is critical because it may impact drug release and also the biocompatibility of the device. Oleogels containing soybean oil as the liquid component and beeswax, a combination of β-sitosterol and lecithin, sorbitan monostearate, sunflower wax, ethyl cellulose, or a combination of γ-oryzanol with β-sitosterol as the gelator were loaded with the drugs dexamethasone, cyclosporine, triamcinolone, vancomycin above the solubility limit and expunged from a syringe to create cylindrical rods for extended drug delivery. Images of the devices were taken to observe the dispersal of drug particles. In vitro drug release in buffer solutions was measured and effective drug diffusivity was determined from a fitted model. Effect of molecular weight and drug binding to the gelator on diffusivity was explored. At loading above the solubility limit, the oleogel formulation contains drug particles that act as distributed d...Continue Reading

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Citations

Jun 12, 2021·AAPS PharmSciTech·Zohreh Sadat Rastegar RamshehFarid Abedin Dorkoosh

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