In vitro release of soluble CD23 by human lymphocytes in ragweed-sensitive versus nonatopic patients following stimulation with ragweed antigen E

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
J BattermanM H Grieco

Abstract

Soluble CD23 is the proteolytic cleavage product of the low affinity receptor (FcERII). Functions of CD23 and its soluble products may include upregulation of IgE production and stimulation of B lymphocyte growth. Soluble CD23 was quantitated in supernatants of lymphocytes from nine ragweed-sensitive and eight nonatopic subjects stimulated in vitro by antigen E (amb Al), crude ragweed extract, and pokeweed mitogen (PWM). Although PWM stimulation produced no significant difference between groups, sCD23 release was significantly elevated in the cells of nonatopic patients stimulated with antigen E and crude ragweed extract (P less than .05). This finding supports the concept of separate pathways of activation by antigen and mitogen for sCD23 release and suggests ragweed-sensitive and nonatopic patients have fundamental differences in the response of sCD23 release to ragweed antigen stimulation.

References

Jan 1, 1979·The Journal of Allergy and Clinical Immunology·R E Rocklin
May 1, 1989·Immunology Today·G DelespesseH Hofstetter
Jul 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M CorominasE Buendia
Jan 1, 1993·Immunology Today·J Y BonnefoyL Flores-Romo
Apr 1, 1993·Kidney International·B Descamps-LatschaJ Zingraff

❮ Previous
Next ❯

Citations

Jul 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leila JacksonJohn C Cambier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
C Fratazzi, C Carini
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Shigetoshi HoriguchiKouichi Kobayashi
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
R J MayerL A Marshall
© 2021 Meta ULC. All rights reserved