In vitro release of substance P from spinal cord slices by capsaicin congeners

European Journal of Pharmacology
A Bucsics, F Lembeck

Abstract

The in vitro release of immunoreactive substance P (I-SP) by capsaicin and three congeners was studied on slices of rat spinal cord upper dorsal horn. Capsaicin and its congeners were all able to stimulate I-SP release, indicating that they act on chemosensitive primary afferents terminating in this region. A positive correlation was found between the I-SP releasing and pain-producing potencies of these compounds. This is in agreement with the concept that primary afferents containing substance P (SP) are involved in the transmission of nociceptive information.

References

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Citations

Jun 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·L A Chahl
Jul 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·Z RózsaV Varró
Feb 28, 1989·European Journal of Pharmacology·R Amann, F Lembeck
Jan 1, 1988·Pharmacology & Therapeutics·L A Chahl
Sep 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hélène BeaudryLouis Gendron
Sep 11, 2012·Phytotherapy Research : PTR·Thomas WeiserSigrun Chrubasik
Apr 4, 2009·Physiological Reviews·Jürgen Sandkühler
Mar 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·D W Harron, W Kobinger

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