In vitro responses of cervine macrophages to bacterial stimulants

Veterinary Immunology and Immunopathology
M L CrossJ F Griffin

Abstract

The function of cervine (deer) mononuclear phagocytes is poorly defined. In the present study, the potential of cervine macrophages to generate phagocytic and immunoregulatory responses following stimulation with bacterial products was investigated. Blood-derived macrophages of red deer were cultured in vitro with particulate stimulants (Mycobacterium bovis BCG and Staphylococcus aureus SAC) or soluble stimulants (M. bovis PPD and Escherichia coli LPS), prior to assessment of phagocytic responses, prostaglandin secretion and cytokine production. Particulate stimulants induced vigorous phagocytic responses (superoxide anion generation, lysosomal enzyme release), secretion of prostaglandin E2 and transcription of mRNA specific for the cytokines IL-1 beta, IL-10 and TNF alpha, while soluble products invoked weaker responses. These results are discussed in relation to the role of cervine mononuclear phagocytes in regulating and participating in inflammatory and immune processes relevant to bacterial challenge.

References

Feb 1, 1989·Veterinary Immunology and Immunopathology·J F Griffin
Jan 1, 1996·Veterinary Immunology and Immunopathology·M L CrossG S Buchan

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Citations

Mar 17, 1999·Veterinary Immunology and Immunopathology·M L CrossC G Mackintosh
May 23, 1998·Gene·J C BeyerW P Cheevers
Dec 23, 2008·American Journal of Respiratory Cell and Molecular Biology·Tsutomu ShinoharaYoshimi Shibata

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