PMID: 2502084Jan 1, 1989Paper

In vitro responsiveness of human testicular DNA synthesis to gonadotropins

Archives of Andrology
A OkuyamaT Sonoda

Abstract

To evaluate the responsiveness of spermatogenesis in the normal human testis to human menopausal gonadotropin (hMG) and human chorionic gonadotropin (hCG), the DNA synthesis of spermatogonia was investigated using 3H-thymidine uptake by cultured tissue fragments of human testis with or without treatment with hCG and/or hMG. Two groups treated with different concentrations of hCG showed no difference in 3H-thymidine incorporation into testicular tissue compared with untreated control. In two other groups treatment with combined hMG/hCG in different concentrations induced significant changes in 3H-thymidine incorporation compared with control (p less than 0.01, p less than 0.01). Combined hMG/hCG treatment was effective in inducing spermatogenesis by normal human testicular tissue.

References

Jan 1, 1987·Archives of Andrology·M NakamuraT Sonoda
Sep 12, 1985·The New England Journal of Medicine·D M FinkelP J Snyder
Dec 1, 1972·Experimental Cell Research·Y Nishimune, T Komatsu
Jan 1, 1973·The Journal of Clinical Endocrinology and Metabolism·R M BoyarL Hellman
Nov 1, 1968·Fertility and Sterility·W Futterweit, A J Sobrero
Oct 15, 1982·Biochemical and Biophysical Research Communications·T HanejiY Nishimune
Oct 1, 1964·Experimental Cell Research·A STEINBERGERW H PERLOFF

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Citations

Nov 16, 2004·Molecular and Cellular Endocrinology·Nafis A Rahman, Ilpo T Huhtaniemi
Feb 25, 2006·Human Reproduction·V RouletN Dejucq-Rainsford

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