Abstract
The schedule-dependent interaction of paclitaxel and cisplatin was studied in four human carcinoma cell lines: non-small cell lung cancer, A549; breast cancer, MCF7; ovarian cancer, PA1; and colon cancer, WiDr cells. The cells were exposed simultaneously to the drugs for 24 h and sequentially to paclitaxel first for 24 h followed by cisplatin for 24 h, or vice versa, and then incubated in drug-free medium for 4 and 3 days, respectively. Cell growth inhibition was then determined by the 1-(4,5-dimethylthiazol-2-yl)-3,5-diphenyltetrazolium bromide (MTT) reduction assay. The effects of drug combinations at the IC80 level were analyzed by the isobologram method. On simultaneous exposure to paclitaxel and cisplatin, additive and subadditive (slight antagonistic) effects were observed in A549, MCF7, and PA1 cells, while sub-additive and protective (antagonistic) effects were observed in WiDr cells. On sequential exposure to paclitaxel first, followed by cisplatin, additive effects were observed in all cell lines. On sequential exposure to cisplatin first, followed by paclitaxel, additive effects were observed in PA1 cells, while additive, sub-additive, and protective effects were observed in A549, MCF7, and WiDr cells. These findings...Continue Reading
Citations
Aug 16, 2001·Cancer·H L LinC W Chi
Feb 26, 2005·Cancer Chemotherapy and Pharmacology·Risa TanakaShuji Nakano
May 6, 2005·Cancer Chemotherapy and Pharmacology·Risa TanakaShuji Nakano
Aug 3, 2005·Cancer Chemotherapy and Pharmacology·Yuji ToiyamaMasato Kusunoki
Mar 12, 2009·Cancer Chemotherapy and Pharmacology·Xiao-Li LiChun-Su Yuan
Jul 23, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sang-We KimJung Sin Lee
Nov 27, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C H SmorenburgJ Verweij
Jul 27, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P RogersL R Kelland
Dec 9, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S CascinuR Cellerino
Feb 13, 2001·Critical Reviews in Oncology/hematology·W ZoliD Amadori
May 29, 2008·Annals of Surgical Oncology·Yoichi SakuraiYutaka Tsutsumi
Jul 24, 2010·Head & Neck·Filip Yves F L De VosEsther van Meerten
May 24, 2001·The Journal of Urology·Y S PuT C Hour
Mar 16, 2001·Expert Opinion on Pharmacotherapy·I Sekine, N Saijo
Dec 17, 2014·Experimental Cell Research·Steven BusschotsBritta Stordal
Mar 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Judith HurleyDennis J Slamon
Jan 22, 2000·Radiation Oncology Investigations·G P AmorinoH Choy
Jul 19, 2005·Japanese Journal of Clinical Oncology·Yujiro FujieMorito Monden
Oct 3, 1999·British Journal of Cancer·H L LinC W Chi
May 17, 2018·Royal Society Open Science·Azadeh GhodsAdam McCluskey
Apr 16, 2013·Cell Biology International·Hongxu ChenPing Chen
May 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jian ZhangZhimin Shao
Oct 24, 2012·Molecular Pharmacology·Shannon K StevensPamela K Hanson
Mar 20, 2003·Molecular Pharmacology·Mazin A MoufarijCarleen Cullinane
Dec 30, 2015·The Oncologist·Olivier M VandervekenJan Vermorken
Feb 23, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Weiwei ShengJianping Zhou
Mar 7, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·L FusoI Vergote
Jun 27, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Shimpei SugiuraHisashi Oshiro
Jan 3, 2018·Oncotarget·Yongshun ChenChunyu He
Jun 2, 2009·American Journal of Hematology·Shih-Hung YangAnn-Lii Cheng
Jan 14, 2017·Pancreas·Ramya ThotaJordan D Berlin
Dec 2, 2015·Oncology Letters·Byeong Seok SohnSung Rok Kim
Oct 17, 2002·The Journal of Biological Chemistry·Danielle R MercatanteRyszard Kole
Dec 5, 2003·Alimentary Pharmacology & Therapeutics·S ShoreJ P Neoptolemos
Aug 11, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Manish A. Shah, Gary K. Schwartz
Oct 10, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C-C LinY-C Lee