In Vitro Selection Combined with Ribosomal Translation Containing Non-proteinogenic Amino Acids

Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]
Tomoshige Fujino, Hiroshi Murakami

Abstract

The potential applications of non-proteinogenic amino acids have increased continuously since the introduction of these molecules into a ribosomal translation system. An increasing number of studies concerning topics, such as the addition of an artificial function to a protein, cellular expression of a protein with an artificial residue, and development of an artificial peptide with a novel function, have been done using these molecules. Here, we describe recent studies that elucidate the compatibility of non-proteinogenic amino acids with ribosomal translation. We also describe the development of a simple and high-speed selection method and its potential application for the creation of a novel functional peptide with non-proteinogenic amino acids. As these studies have expanded the diversity of the artificial peptide library and increased the speed of novel functional peptide selection, they will significantly facilitate the development of new molecules, such as pharmaceutical drug candidates and bioassay probes.

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Citations

Jan 26, 2016·Journal of the American Chemical Society·Tomoshige FujinoHiroshi Murakami
May 19, 2017·Organic & Biomolecular Chemistry·Christine M RingT Ashton Cropp
Feb 9, 2021·Chemical Communications : Chem Comm·Taishi KondoHiroshi Murakami
Nov 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhenbo YuanYijian Rao
Nov 6, 2018·Chemical Reviews·Yichao HuangHiroaki Suga
Jul 2, 2021·Biochemistry·Mia A ShandellVirginia W Cornish

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