In vitro selection of influenza B viruses with reduced sensitivity to neuraminidase inhibitors.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
S HatakeyamaYoshihiro Kawaoka

Abstract

We and others have previously isolated influenza B viruses with reduced sensitivity to neuraminidase (NA) inhibitors (oseltamivir and zanamivir) from patients who were never exposed to these drugs. It was unclear whether the NA substitutions found in these influenza B isolates arose spontaneously or were caused by selective pressure. Here, we obtained influenza B viruses with reduced NA inhibitor sensitivity by in vitro selection with NA inhibitors. We found that these viruses possessed the same NA substitutions as those previously found in viruses isolated from untreated patients. These results suggest that these NA substitutions were selected in patients who were treated with an NA inhibitor and that the resistant variants were then transmitted to others.

References

Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M KrystalD C Wiley
Aug 1, 1997·The Journal of Infectious Diseases·J M ColacinoG M Air
Oct 21, 1998·The Journal of Infectious Diseases·L V GubarevaR G Webster
Aug 10, 2000·Antiviral Research·J L McKimm-Breschkin
Feb 16, 2006·The Journal of Infectious Diseases·Michael G IsonFrederick G Hayden
Apr 5, 2007·JAMA : the Journal of the American Medical Association·Shuji HatakeyamaYoshihiro Kawaoka
Dec 7, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Vanessa EscuretOlivier Ferraris

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Citations

Jan 4, 2013·Influenza and Other Respiratory Viruses·Jennifer L McKimm-Breschkin
Apr 4, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Shu-Ming KuoShin-Ru Shih
Sep 10, 2013·Antiviral Research·Andrew J BurnhamElena A Govorkova
Dec 16, 2011·Virology Journal·Wen HeBin Gao
Nov 16, 2018·PloS One·Naranzul TsedenbalNymadawa Pagbajab
Jun 2, 2015·Biological & Pharmaceutical Bulletin·Tadanobu Takahashi, Takashi Suzuki

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