In vitro sensitivity of human parainfluenza 3 clinical isolates to ribavirin, favipiravir and zanamivir

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Anna SmielewskaHamid Jalal

Abstract

Human parainfluenza type 3 (HPIV3) is an important respiratory pathogen. Although a number of potential therapeutic candidates exist, there is currently no licensed therapy or vaccine. Ribavirin (RBV), favipiravir (FVP) and zanamivir (ZNV) are inhibitors with proven activity against influenza and with potential inhibitory activity against HPIV3 laboratory adapted strains in vitro. To evaluate RBV, FVP and ZNV as inhibitors of minimally passaged UK clinical strains of HPIV3 as well as a laboratory adapted strain MK9 in vitro. The inhibitory action of RBV, FVP and ZNV was evaluated against nine minimally passaged clinical strains and a laboratory adapted strain MK9 using plaque reduction and growth curve inhibition in a cell culture model. Clinical isolates were found to be at least as susceptible as the laboratory adapted strains to RBV and FVP and significantly more susceptible to ZNV. However the inhibitory concentrations achieved by ZNV against clinical strains remain prohibitively high in vivo. RBV, FVP and ZNV were found to be effective inhibitors of HPIV3 in vitro. The lack of efficacy of RBV in vivo may be due to inability to reach required therapeutic levels. FVP, on the other hand, is a good potential therapeutic agent ...Continue Reading

Citations

May 26, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Auke E S de ZwartErik A M Verschuuren
Jan 26, 2021·Influenza and Other Respiratory Viruses·Daniel R L GreiffHannah C Moore
Jan 14, 2022·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Auke de ZwartErik Verschuuren

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