In Vitro Skin Permeation Enhancement of Sumatriptan by Microneedle Application

Current Drug Delivery
Buchi N NalluriDiganta Bhusan Das

Abstract

Different dimensions of commercially available microneedle devices, namely, Admin- Patch(®) microneedle arrays (MN) (0.6, 0.9, 1.2 and 1.5 mm lengths) and Dermaroller(®) microneedle rollers (DR) (0.5 and 1mm lengths) were evaluated for their relative efficiency in enhancement of transdermal permeation of Sumatriptan (SMT). Solubility assessment of SMT was carried out using propylene glycol (PG), polyethylene glycol (PEG) in combination with saline (S) at different ratios and the order of solubility was found to be 70:30 > 80:20 > 90:10 %v/v in both PG:S and PEG:S. In vitro skin permeation studies were performed using PG:S (70:30 %v/v) as donor vehicle. A significant increase in cumulative amount of SMT permeated, steady state flux, permeability coefficient and diffusion coefficient values were observed after microneedle treatment, and the values were in the order of 1.5mm MN >1.2mm MN >0.9mm MN >1mm DR >0.6mm MN >0.5mm DR > passive permeation. Lag times were significantly shorter after longer microneedle application (0.24h for 1.5mm MN). Arrays were found to be superior to rollers with similar microneedle lengths in enhancing SMT permeation and may be attributed to higher density of microneedles and force of application onto sk...Continue Reading

Citations

Feb 1, 2020·Expert Opinion on Drug Delivery·Waleed AlsalhiAntonella Tosti
Feb 6, 2017·Drug Delivery and Translational Research·Buchi N NalluriDiganta B Das
Jan 13, 2017·AAPS PharmSciTech·Chandrateja UppuluriDiganta B Das
Oct 27, 2020·Biomedical Microdevices·Leonna DsouzaShaila A Lewis
Oct 21, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cetin TasMark R Prausnitz
Jun 13, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cassie L CaudillJoseph M DeSimone

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