Sep 1, 1976

In vitro stimulation by retinol of porcine pancreatic esterase activity toward esters of short-chain fatty acids

Journal of Biochemistry
T KomuraH Nagayama

Abstract

1. Retinol exerted a remarkable stimulating effect (approx. 260% increase), essentially similar to that (300%) of phytol, on the so-called esterase activity displayed by crude pancreatic lipase [EC 3.1.1.3] toward true solutions of esters, but none of the typical lipase activity toward emulsions of water-insoluble esters. 2. Comparison of the stimulatory effects of retinol derivatives on the esterase activity revealed that retinyl acetate was the most active, being sustantially similar in effect to retinol; retinal was fairly active, while retinoic acid, retinyl palmitate, and beta-ionone were far less active. 3. With various isoprenoid compounds, the efficiency of stimulation increased with the carbon chain length, attaining a maximum at 15 to 20 carbon atoms. Above this chain length the efficiency decreased rapidly. 4. Comparison of the effects of retinol and phytol on the esterase activity of various other lipolytic enzymes indicated that this kind of activator may be relatively specific to porcine pancreatic esterase activity.

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Mentioned in this Paper

Vitamin A
Exertion
Fatty Acids, Volatile
Derivatives
Retinol acetate
Pancreatic lipase
Enzymes, antithrombotic
Pancreatitis
Retinyl palmitate
Isoprenoids

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