PMID: 8993778Jan 1, 1996Paper

In vitro studies during long-term oral administration of specific transfer factor

Biotherapy
G PizzaD Viza

Abstract

153 patients suffering from recurrent pathologies, i.e. viral infections (keratitis, keratouveitis, genital and labial herpes) uveitis, cystitis, and candidiasis were treated with in vitro produced transfer factor (TF) specific for HSV-1/2, CMV and Candida albicans. The cell-mediated immunity of seropositive patients to HSV-1/2 and/or CMV viruses was assessed using the leucocyte migration inhibition test (LMT) and lymphocyte stimulation test (LST) in presence of the corresponding antigens, and the frequency of positive tests before, during and after TF administration was studied. The data were stratified per type of test, antigen and the recipients' pathology, and statistically evaluated. For the LMT, a total of 960 tests were carried out for each antigen dilution, 3 different antigen dilutions were used per test. 240/960 tests (25.4%) were found positive during non-treatment or treatment with unspecific TF, whereas 147/346 tests (42.5%) were found positive when the antigen corresponding to the specificity of the TF administered to the patient was used (P < 0.001). When the data were stratified following pathology, a significant increased incidence of positive tests during specific treatment was also observed (0.0001 < P < 0.05...Continue Reading

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Citations

Oct 9, 2013·Journal of Pharmaceutical and Biomedical Analysis·Emilio Medina-RiveroSonia Mayra Pérez-Tapia
May 20, 2015·Journal of Immunology Research·Nohemí Salinas-JazmínSonia Mayra Pérez-Tapia
Aug 9, 2020·Journal of Personalized Medicine·Anderson O FerreiraEli C F Dijkers

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