In vitro studies indicate that acid catalysed generation of N-nitrosocompounds from dietary nitrate will be maximal at the gastro-oesophageal junction and cardia

Scandinavian Journal of Gastroenterology
A MoriyaK E McColl

Abstract

Dietary nitrate increases saliva nitrite levels and swallowed saliva is the main source of nitrite entering the acidic stomach. In acidic gastric juice, this nitrite can generate potentially carcinogenic N-nitrosocompounds. However, ascorbic acid secreted by the gastric mucosa can prevent nitrosation by converting the nitrite to nitric oxide. To study the potential for N-nitrosocompound formation in a model simulating salivary nitrite entering the acidic stomach and the ability of ascorbic acid to inhibit the process. Concentrations of ascorbic acid, total vitamin C, nitrite, nitrosomorpholine, oxygen and nitric oxide were monitored during the experiments. The delivery of nitrite into HCl containing thiocyanate resulted in nitrosation of morpholine, with the rate of nitrosation being greatest at pH 2.5. Under anaerobic conditions, ascorbic acid converted the nitrite to nitric oxide and prevented nitrosation. However, in the presence of dissolved air, the ascorbic acid was ineffective at preventing nitrosation. This was due to the nitric oxide combining with oxygen to reform nitrite and this recycling of nitrite depleting the available ascorbic acid. Further studies indicated that the rate of consumption of ascorbic acid by nitr...Continue Reading

Citations

May 28, 2014·Journal of Gastroenterology and Hepatology·Katsunori Iijima, Tooru Shimosegawa
Sep 14, 2007·Scandinavian Journal of Gastroenterology·Jonathan J ManningKenneth E L McColl
Oct 18, 2005·Alimentary Pharmacology & Therapeutics·S MehtaM Rhodes
May 10, 2003·Scandinavian Journal of Gastroenterology·K IijimaK E L McColl
Jul 3, 2008·Digestion·D PohlUNKNOWN Kandahar Study Group
Jan 28, 2009·Scandinavian Journal of Gastroenterology·Fumitake IshiyamaTooru Shimosegawa
Sep 10, 2016·Biological Chemistry·Christine C HelmsDaniel B Kim-Shapiro
May 28, 2019·Nature Reviews. Disease Primers·Yonne PetersPeter D Siersema
Jun 28, 2018·Environmental Science and Pollution Research International·Chetan P S Ahada, Surindra Suthar
Jul 27, 2012·The Journal of Nutrition·Grietje HoltropSilvia W Gratz
May 6, 2021·International Journal of Molecular Sciences·Zahra BahadoranAsghar Ghasemi
Apr 23, 2011·Journal of Agricultural and Food Chemistry·Pablo Gomes FerreiraIone Salgado
Jan 20, 2010·Nitric Oxide : Biology and Chemistry·Bárbara S RochaJoão Laranjinha

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