PMID: 11913825Mar 27, 2002Paper

In vitro studies of a photo-oxidized bovine articular cartilage

Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine
M K AkensJ A Auer

Abstract

Bovine articular cartilage was photo-oxidized and cultured with native articular bovine cartilage and synovial membrane to study the interaction between these tissues mimicking the physiological situation in the joint. The photo-oxidation was applied as a pretreatment of cartilage for future use in cartilage resurfacing procedures in joints. Properties of the transplant were assessed by testing the production of local mediators, such as nitric oxide (NO) and prostaglandin E2 (PGE2), and neutral metalloproteinase activities under normal conditions and after stimulation with various stimulants representative of inflammatory changes in pathophysiological conditions. Unlike normal cartilage photo-oxidized cartilage did not release significant amounts of NO and PGE2 and showed less gelatinolytic and caseinolytic activity compared to native bovine articular cartilage. Enzyme activity of the combined cultures was at a level intermediate between that of photo-oxidized cartilage and native cartilage cultures alone. In contrast to normal cartilage, living chondrocytes were not visible in photo-oxidized cartilage using live/dead staining. These results indicate, that the photo-oxidized cartilage may have a beneficial effect on adjacent na...Continue Reading

References

Nov 1, 1991·Veterinary Surgery : VS·M R DesjardinsN C Palmer
May 1, 1992·Research in Veterinary Science·S A MayP Lees
Oct 1, 1991·Acta Orthopaedica Scandinavica·G N HommingaA J van der Linden
Jan 1, 1991·The Journal of Bone and Joint Surgery. British Volume·B F ShahgaldiG Bentley
Jan 1, 1984·Annual Review of Medicine·G E Friedlaender, H J Mankin
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Jan 26, 1993·Biochemical Pharmacology·B MayerK Schmidt
Jan 1, 1995·The Journal of Bone and Joint Surgery. American Volume·H K OuterbridgeR E Outerbridge
May 1, 1994·Journal of Biomedical Materials Research·M A MooreB K McIlroy
Jul 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D A HendricksonG Lust
Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson
Feb 1, 1994·Cryobiology·K MuldrewL E McGann
Nov 1, 1993·Journal of Periodontal Research·H Birkedal-Hansen
Oct 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·K FukudaS Tanaka
May 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L ManfieldG A Murrell
Feb 1, 1997·Arthritis and Rheumatism·T HayashiH E Jasin
Jan 1, 1997·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·L HangodyI Udvarhelyi
Oct 24, 1998·Cell Transplantation·H YangL McGann
Dec 30, 1999·Veterinary Immunology and Immunopathology·J P Scheerlinck
Oct 1, 1953·Archives of Biochemistry and Biophysics·L WEILA R BUCHERT
Jan 1, 1995·Tissue Engineering·D A GrandeP A Lucas

❮ Previous
Next ❯

Citations

Dec 10, 2008·Tissue Engineering. Part B, Reviews·Christopher M Revell, Kyriacos A Athanasiou
Mar 21, 2006·BMC Musculoskeletal Disorders·Jill S Kawalec-CarrollDustin Prins
May 4, 2012·BMC Veterinary Research·Matthias A ZumsteinDominik C Meyer
Nov 26, 2013·Journal of Biomechanics·Derek D CissellKyriacos A Athanasiou
Jun 26, 2007·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Vincent J HetheringtonDaniel Nadler
Dec 4, 2014·Journal of Biomechanics·Stephanie GrenierPeter A Torzilli
Dec 18, 2013·Journal of Biomechanics·Sevan R OungoulianGerard A Ateshian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.