In vitro studies of the impact of maribavir on CMV-specific cellular immune responses

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Daniel StachelMichael Boeckh

Abstract

Ganciclovir has demonstrated immunosuppressive effects in vitro which may lead to delayed cytomegalovirus (CMV)-specific immune reconstitution when the drug is given prophylactically. Maribavir is a new and more potent anti-CMV drug that is under evaluation for therapeutic use in transplant recipients. The objective of this study was to evaluate the potential effect of maribavir on CMV-specific T cell function in comparison to ganciclovir. In ten immunocompetent CMV seropositive donors, maribavir and ganciclovir were compared over a broad range of concentrations (0.2-500μM) regarding their effects on lymphoproliferation, CMV-specific CD4+ and CD8+ cytokine expression, T cell multifunctionality, degranulation and apoptosis. Maribavir inhibited lymphocyte proliferation at concentrations of 50μM and above, however, cytokine expression, cellular degranulation and multifunctionality of CD4+ and CD8+ T cells in response to CMV lysate and pp65 peptide mix were not impaired except at the highest concentration of 500μM. Ganciclovir inhibited lymphoproliferative responses starting at 10μM. As with maribavir, other cellular responses following stimulation with CMV lysate and pp65 peptide mix were only impaired at the highest concentration...Continue Reading

References

Jun 1, 1991·The Journal of Clinical Investigation·W HeagyR W Finberg
Dec 1, 1987·The Journal of Infectious Diseases·R A BowdenJ D Meyers
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·Y C ChengS P Grill
Jun 25, 2003·Antimicrobial Agents and Chemotherapy·Stephanie L WilliamsEarl R Kern
Jun 28, 2006·Antimicrobial Agents and Chemotherapy·Sunwen ChouGail I Marousek
Sep 12, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·W Lawrence DrewSunwen Chou
Jun 21, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Minoo BattiwallaPhilip L McCarthy
Sep 18, 2009·Journal of Virology·Fu-Zhang WangJoseph S Pagano
Aug 5, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·R K AveryS Villano
Aug 12, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Margaret PollackMichael Boeckh

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Citations

Jun 21, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Tomas ReischigMirko Bouda
Dec 7, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rachel Hellemans, Daniel Abramowicz

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