PMID: 43895Dec 1, 1979

In vitro studies on adenomatosis of the colon and rectum

Journal of Medical Genetics
B S Danes, T Alm

Abstract

Cell culture studies on adenomatosis of the colon and rectum (ACR) suggested that the clinical phenotype, colonic adenomas which become malignant recognised as a single clinical entity, may not be entirely the result of a single dominant mutation. Of the dermal cultures containing both epithelioid and fibroblastic cells established from six affected subjects from six unrelated ACR families, four showed increased tetraploidy and two did not. Of similar cultures established from four affected subjects form families with ACR associated with sebaceous cysts in consecutive generations, three did and one did not have increased tetraploidy. Irrespective of the in vivo relationship of increased tetraploidy to colonic cancer, the cultures from seven ACR patients had populations of tetraploid cells, at least in vitro, with chromosome instability. Such a difference in expression of the ACR genotype in vitro suggested genetic heterogeneity within this clinically defined group.

References

Dec 1, 1975·Cancer·B S Danes
Feb 1, 1976·Journal of Medical Genetics·B S Danes
Apr 1, 1969·The Journal of Experimental Medicine·B S Danes, A G Bearn
Aug 1, 1952·Annals of Eugenics·C E DUKES
Oct 1, 1952·American Journal of Surgery·R C SCHAFFER
Mar 1, 1953·British Journal of Cancer·C O NORDLING
Sep 15, 1963·Experientia·A J FRYAR, R J GIBBS

Citations

Jul 1, 1983·Diseases of the Colon and Rectum·B S Danes
Jun 21, 1980·Lancet·J D DelhantyB C Morson
Nov 1, 1985·Scandinavian Journal of Gastroenterology·L B SvendsenB S Danes
Apr 1, 1981·Scandinavian Journal of Gastroenterology·B S Danes, T Alm
Feb 12, 2008·Cirugía española·Teresa Ramón Y Cajal Asensio
Aug 1, 1980·Clinical Genetics·B S DanesL B Svendsen

Related Concepts

Aneuploid Cell
Chromosomes, Human
Malignant Tumor of Colon
Karyotype Determination Procedure
Multiple Endocrine Neoplasia
Genealogical Tree
Skin

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