PMID: 42376Jan 1, 1979

In vitro studies on Borna virus. II. Properties of the virus

Archives of Virology
K Danner, A Mayr


Successful cultivation and titration of Borna disease virus in cell cultures enabled detailed studies of the virus properties. Borna virus is labile towards treatment with heat, pH 3.0 and lipid solvents. It is relatively stable at low temperatures and in frozen state. It is easily inactivated by ultraviolet light as e.g. vesicular stomatitis virus. After ultrafiltration studies, the size of the infectious virus unit is between 80 and 100 nm. Its buoyant density in cesium chloride is 1.165 g per ml. The one step multiplication curve shows that Borna virus has a replication cycle of about 2 days in BSC 1 cells. In growth experiments using antimetabilites it behaves like certain RNA containing viruses. As its multiplication is not inhibited by bromo- and iododeoxyuridine and actinomycin D, no DNA step seems to be involved in virus synthesis. Regarding these properties and the intracellular antigen distribution as shown by fluorescent antibodies, it is not possible to attribute Borna virus to any of the established virus groups.


Jan 1, 1981·Journal of Medical Virology·L StitzH Ludwig
Jul 4, 2001·Clinical Microbiology Reviews·K M Carbone
Oct 29, 2005·Journal of Virology·C David Lytle, Jose-Luis Sagripanti
Mar 22, 2002·Journal of Virology·Madiha S IbrahimKazuyoshi Ikuta
Dec 12, 2012·The Journal of General Virology·Paula M KinnunenOlli Vapalahti
Mar 2, 2019·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
May 1, 1997·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·R Dürrwald, H Ludwig


Jan 1, 1964·Biochemical and Biophysical Research Communications·J Taylor
Jan 1, 1973·Medical Microbiology and Immunology·T H LudwigL Groh
Mar 1, 1972·Virology·W P Parks, G J Todaro
Jun 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·A Mayr, K Danner
Jul 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·V ter MeulenH Koprowski
Jan 1, 1972·Current Topics in Microbiology and Immunology·V ter MeulenD Müller
Jan 1, 1965·Archiv für die gesamte Virusforschung·O PALACIOS

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