PMID: 5902570Jan 1, 1966

In vitro studies on radiation lymphoid recovery of mouse spleen

The Journal of Experimental Medicine
A Globerson

Abstract

In vitro studies, utilizing an organ culture method were reported on mutual interactions between irradiated spleen, normal bone marrow, and thymus. It has been shown; (a) that singly isolated spleen explants were incapable of lymphoid regeneration, (b) thymus had no stimulatory effect on spleen regeneration, (c) bone marrow interacted synergistically with spleen leading to appearance of lymphoid cells which were not detected in singly isolated bone marrow or spleen, and (d) no stimulation of lymphopoiesis in bone marrow was conferred by thymus in the absence of spleen. The results are discussed in terms of possible mechanisms involved in lymphoid radiation recovery in vivo.

References

Apr 24, 1965·Nature·T MekoriM Feldman
Aug 27, 1965·Science·A Globerson, R AUERBACH
Mar 10, 1956·Nature·C E FORDJ F LOUTIT
Dec 1, 1957·Journal of Cellular Physiology. Supplement·C C CONGDON
Feb 16, 1963·Lancet·C E FORD, H S MICKLEM
Mar 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·D METCALF, R WAKONIG-VAARTAJA

Citations

Aug 5, 1967·Nature·P K KalpaktsoglouR A Good
Nov 1, 1966·The Journal of Experimental Medicine·A Globerson, R AUERBACH
Aug 1, 1967·The Journal of Experimental Medicine·A Globerson, R AUERBACH
Oct 7, 1966·Annals of the New York Academy of Sciences·R AUERBACH
Feb 28, 1975·Annals of the New York Academy of Sciences·A GlobersonD Friedman
Apr 1, 1966·Experimental Cell Research·R AUERBACH, A Globerson
Nov 1, 1971·Journal of Dental Research·R AUERBACH

Related Concepts

Marrow
Lymphoid Tissue
Effects of Radiation
Natural Regeneration
Spleen
Thymus Gland
Culture Techniques

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