In vitro studies on subtypes and regulation of active cell death

Toxicology in Vitro : an International Journal Published in Association with BIBRA
W BurschR Schulte-Hermann

Abstract

Active cell death (ACD) comprises several subtypes as indicated by morphology at light- and electron-microscopical level: for example type I ACD or apoptosis, with nuclear condensation, fragmentation, cytoplasmic condensation; type II ACD, nuclear pyknosis, cytoplasmic autophagy. Morphologically different types of cell death are considered to reflect differences in the underlying biochemical and molecular events eventually leading to cell collapse. However, currently no simple biochemical or molecular marker for detection of ACD subtypes is available and, therefore, morphological methods are still required to classify ACD. Sometimes, distinction of ACD from necrosis may be equivocal. Type I ACD occurs in primary hepatocyte cultures treated with TGF-beta1 and in colonie adenoma cell cultures treated with the proteinkinase C inhibitor H7 (1[5-iso-quinolylsulfonyl]-2-methylpiperazine). The anti-survival activity of TGF-beta1 was confirmed in vivo as TGF-beta1 strongly induced apoptosis in normal tissue and in preneoplastic lesions of rat liver. Type II ACD was observed in human mammary carcinoma cells (MCF-7) after treatment with tamoxifen. The anti-survival activity of H7 and of the anti-oestrogens tamoxifen, 4-hydroxy-tamoxifen,...Continue Reading

References

Apr 1, 1992·International Journal of Radiation Biology·R J CollinsJ F Kerr
Sep 1, 1992·Cancer Metastasis Reviews·M P TenniswoodJ E Welsh
Jun 1, 1992·Trends in Pharmacological Sciences·W BurschR Schulte-Hermann
Jun 1, 1991·Biochemical Pharmacology·M J TurnerD B Everman
Nov 1, 1990·Endocrine Reviews·V C Jordan, C S Murphy
Jul 1, 1989·The Journal of Pathology·D J Pritchard, W H Butler
Jun 1, 1973·Teratology·J U Schweichel, H J Merker
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P O Seglen, P B Gordon
Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Nov 1, 1994·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·M CejnaW Bursch
May 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B Grasl-KrauppR Schulte-Hermann
Mar 1, 1994·Trends in Pharmacological Sciences·H Wiseman
Sep 1, 1993·Journal of the National Cancer Institute·A M WärriP L Härkönen
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L M SchwartzB A Osborne
Apr 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L MüllauerR Schulte-Hermann

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Citations

Jan 25, 2005·Cancer Biotherapy & Radiopharmaceuticals·Zoltán MarcsekAnna Tompa
Jul 12, 2005·Oncogene·Christian Schwerk, Klaus Schulze-Osthoff
Jan 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Susann PatschanMichael S Goligorsky
Jun 9, 2004·International Journal of Occupational Safety and Ergonomics : JOSE·Jolanta Skowroń, Lidia Zapór
May 1, 1999·Alternatives to Laboratory Animals : ATLA·E Kuchowicz, K Rydzynski
Feb 24, 2001·Annals of the New York Academy of Sciences·W BurschR Schulte-Hermann

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