In vitro studies on the characterization of cellular proliferation following neuronal injury in the adult rat brain

Journal of Neuroimmunology
I R KatzD J Reis

Abstract

While brain injury elicits local cellular proliferation, it is not known whether cells not originating in brain substantially participate in the response. We assessed the time course and phenotype of dividing cells following neuronal damage initiated by microinjection of the neurotoxin ibotenic acid into one caudate nucleus (CN) in adult rat. Proliferation was determined in an in vitro assay measuring incorporation of [3H]thymidine into cellular DNA in cultures of lesioned and uninjected CN. Cellular phenotypes were determined immunocytochemically. Our results show that the proliferative response to brain injury has a rapid onset, peaks within 2 weeks and persists. The majority of proliferating cells that respond to selective neuronal injury are not intrinsic to the central nervous system, but rather are of hematic origin, involving monocytes, macrophages and T-helper lymphocytes.

References

Oct 27, 1978·Brain Research·V K Singh, D Van Alstyne
Feb 1, 1979·The Journal of Comparative Neurology·C GallG Lynch
Jul 1, 1985·The Journal of Experimental Medicine·W A JefferiesA F Williams
Jan 1, 1988·Annals of the New York Academy of Sciences·T OlssonL Klareskog
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D GiulianR L Allen
Dec 1, 1985·The Journal of Cell Biology·D Giulian, T J Baker
Oct 1, 1972·Journal of Neuropathology and Experimental Neurology·A E Stenwig
Apr 1, 1980·Journal of the Neurological Sciences·A FontanaP Grob
Jun 1, 1980·The Journal of Cell Biology·K D McCarthy, J de Vellis
Dec 1, 1983·Journal of the Neurological Sciences·S U KimL B Rorke
Jan 1, 1981·Differentiation; Research in Biological Diversity·M OsbornK Bayreuther
Apr 1, 1982·Immunobiology·M Oehmichen
Oct 1, 1963·Journal of Neuropathology and Experimental Neurology·B W KONIGSMARK, R L SIDMAN

❮ Previous
Next ❯

Citations

Sep 1, 1992·Neurochemical Research·W T NortonC F Brosnan
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S YamamotoD J Reis
Jun 6, 2015·Drugs : Education, Prevention, and Policy·William Haydock
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·J BruhwylerF Carreer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.