PMID: 15374468Nov 1, 1990Paper

In vitro studies on the OH* and O2(-*) free radical scavenger properties of idebenone in chemical systems

Archives of Gerontology and Geriatrics
I SemseiI Zs -Nagy

Abstract

OH(*) free radicals were generated by Fenton reaction in the presence of bovine serum albumin (BSA). The decreasing water-solubility of BSA with increasing Fe(2+) concentrations of the system is a sensitive indicator of the cross-linking effects of the OH(*) free radicals. Idebenone (oxidized form) was solubilized for this experiment in DMSO and added to the system in final concentrations of 0.01 or 0.1%. Neither of these concentrations displayed any protective effect against the insolubilization of BSA. Therefore, oxidized idebenone has to be considered as a substance which reacts with OH(*) free radicals slower than the BSA itself, i.e., its oxidized form is not an efficient scavenger of this type of free radicals under the given circumstances. The ability of idebenone to scavenge superoxide radicals was tested in ( [Formula: see text] ) the pyrogallol system; and (ii) the xanthine-xanthine oxidase-nitro blue tetrazolium (XXO-NBT) system. Idebenone did not show any O(2)(-*) radical scavenging ability as revealed by these two in vitro methods, in the concentration ranges studied (up to 75 or 220 microg/ml, respectively). On the contrary, an increasing O(2)(-*) radical generation was observed with increasing concentrations of t...Continue Reading

References

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Oct 22, 2008·Journal of Clinical Anesthesia·Stanley Muravchick

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Citations

Nov 1, 1990·Archives of Gerontology and Geriatrics·I Zs -Nagy, R A Floyd
Nov 1, 1992·Archives of Gerontology and Geriatrics·U SeninM Fioravanti
May 1, 1993·American Journal of Botany·A Jonathan Shaw, James F Gaughan

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