PMID: 708005Sep 1, 1978Paper

In vitro studies with UK-18,892, a new aminoglycoside antibiotic

Antimicrobial Agents and Chemotherapy
S JevonsK W Brammer

Abstract

The antibacterial activity of UK-18,892, a new semisynthetic aminoglycoside, was examined against aminoglycoside-susceptible and aminoglycoside-resistant clinical isolates of gram-negative bacilli and Staphylococcus aureus. UK-18,892 had a similar degree of activity to those of amikacin and kanamycin A against aminoglycoside-susceptible bacteria but was less potent than gentamicin against all isolates except Providencia spp. UK-18,892 was highly active against aminoglycoside-resistant bacteria, inhibiting 93% of the 268 isolates examined at 12.5 mug/ml. Amikacin was similarly active, whereas gentamicin inhibited only 14% of these isolates at 12.5 mug/ml.

References

Sep 24, 1977·Lancet·K A Price, G M Chudzik
Feb 17, 1977·The New England Journal of Medicine·C R SmithP S Lietman
Mar 1, 1978·The Journal of Antimicrobial Chemotherapy·I PhillipsK P Shannon
Apr 1, 1976·Antimicrobial Agents and Chemotherapy·J J RahalN H Moldover
Dec 1, 1973·Antimicrobial Agents and Chemotherapy·L S Young, W L Hewitt
Jun 1, 1974·Antimicrobial Agents and Chemotherapy·M E Levison, D Kaye

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