Abstract
Infections caused by parasites in humans represent one of the main public health concerns. Amoebiasis, a parasitic infection caused by Entamoeba histolytica (E. histolytica), is considered endemic in Mexico, where Argemone mexicana (A. mexicana) has been used in traditional medicine to treat intestinal parasitic diseases. The objective of this work was to evaluate the potential biological activity of A. mexicana on E. histolytica. For this purpose, a methanolic extract was prepared from A. mexicana leaves, and a differential fractionation was carried out with solvents of different polarities. The inhibitory capacities of the extract and its fractions were evaluated in vitro using HM1-IMSS, a strain of Entamoeba histolytica. A. mexicana extract was found to have a growth-inhibiting activity for E. histolytica, showing IC50 = 78.39 μg/mL. The extract was characterized phytochemically, and the methanolic extract fractions were analyzed by liquid chromatography (HPLC) and mass spectrometry (MS). Berberine and jatrorrhizine were present in the active fractions, and these compounds may be responsible for the antiparasitic activity. The identification of amoebicidal activity of A. mexicana on E. histolytica gives support to the tradit...Continue Reading
References
Jan 6, 2000·Postgraduate Medical Journal·B D SharmaM Rathee
Feb 3, 2000·Journal of Clinical Microbiology·T MeriS Meri
Aug 27, 2003·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Yuh-Chwen ChangYang-Chang Wu
Jun 1, 1990·Applied and Environmental Microbiology·M H ZwieteringK van 't Riet
Aug 19, 2007·FEBS Letters·Yan YuYi-Zeng Liang
Dec 17, 2009·Natural Product Research·Sarita SinghV B Pandey
Sep 15, 2010·Expert Opinion on Investigational Drugs·Parameswara Rao VuddandaSanjay Singh
Nov 10, 2012·Gut Microbes·Anjan DebnathSharon L Reed
Mar 1, 2013·BMC Complementary and Alternative Medicine·Hamisi M MaleboIsaiah O Ndiege
Aug 28, 2013·Current Topics in Medicinal Chemistry·Jorge Rubio-Pina, Felipe Vazquez-Flota
Jun 1, 1987·Journal of Chemical Ecology·M A SalehN M Taha
Mar 8, 2014·Malaria Journal·Fidele Ntie-KangLuc Meva'a Mbaze
Jul 1, 2014·ISRN Pharmacology·Hossein MahmoudvandSareh Jahanbakhsh
Nov 6, 2014·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yan LiBaolin Bian
Dec 18, 2014·International Journal for Parasitology. Drugs and Drug Resistance·Claudia Simoes-PiresPhilippe Christen
Jun 10, 2015·BMC Complementary and Alternative Medicine·Chen-Wen XiaoGuo-Lian Bao
Aug 29, 2016·The Lancet Global Health·Ali H MokdadChristopher J L Murray
May 26, 2017·Pharmacognosy Research·Fernando CalzadaLilian Yepez Mulia
Jun 5, 2017·Microbial Pathogenesis·Gabriela Jasso DíazPedro Mendoza de Gives
Sep 13, 2017·Journal of Intercultural Ethnopharmacology·Gil Alfonso Magos-GuerreroOmar F Carrasco
Nov 12, 2017·Parasites & Vectors·Valentine C MbatchouBaldwyn Torto
Nov 22, 2017·Cells·Erika Pineda, Doranda Perdomo
May 29, 2018·Drugs·Elizabeth A Ashley, Aung Pyae Phyo
Citations
May 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ramiro Quintanilla-LiceaÁngel David Torres-Hernández
May 19, 2020·The Korean Journal of Parasitology·Joel Horacio Elizondo-LuevanoAbelardo Chávez-Montes
Feb 5, 2021·Parasitology·Saeed NezaratizadeFaham Khamesipour
Feb 23, 2020·Journal of Ethnopharmacology·Fernando Calzada, Elihú Bautista