'In vitro' study of chemotherapeutic activity of sulphimidazole on some sensitive and metronidazole-resistant Trichomonas vaginalis strains

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
M MalagoliM Castelli

Abstract

Trichomonacidal treatment based on 5-nitroimidazoles is problematic both when Metronidazole, the drug of choice, is ineffective owing to the presence of resistant strains and when bacterial aerobic infections are present. Sulphimidazole (SIZ) possesses two distinct functional groups: one sulphonamide, the other 5-nitroimidazole. Since SIZ is active against aerobic and anaerobic bacteria, we set out to discover whether, in view of the presence of the 5-nitroimidazole group, it could also be effective against Trichomonas vaginalis. Twelve strains of T. vaginalis were cultured in Modified Thioglycate Medium in anaerobic conditions; subsequently, their growth was monitored in the presence of Metronidazole (MZ), SIZ, Sulphamethoxazole (SMX), Trimethoprim (TMP) and their associations. Eight strains proved to be sensitive to Metronidazole (minimum lethal concentration=0.5 microgml(-1)) and four to be resistant (minimum lethal concentration=40-60 microgml(-1)). SIZ was active against both the sensitive and the Metronidazole-resistant strains (minimum lethal concentrations=0.5-1 and 10 microgml(-1), respectively), thus showing that the chemotherapeutic activities of the two functional groups coexisting in SIZ remain unimpaired.

References

May 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M CastelliI Galatulas
Feb 5, 1988·Science·P PiotJ M Mann
Feb 1, 1987·The Journal of Infectious Diseases·A PhilipC Rogers
Nov 1, 1970·The Journal of Obstetrics and Gynaecology of the British Commonwealth·I De Carneri, R e Di
Apr 1, 1984·Sexually Transmitted Diseases·J N Krieger
Feb 1, 1984·The British Journal of Venereal Diseases·D A StreetJ P Ackers
Feb 1, 1980·The Journal of Infectious Diseases·A C Fouts, S J Kraus
Mar 1, 1995·Sexually Transmitted Diseases·J N Krieger
Feb 1, 1993·The Journal of Antimicrobial Chemotherapy·D I Edwards
Oct 6, 2000·The Journal of Antimicrobial Chemotherapy·M CastelliG Baggio

Related Concepts

1-methyl-2-((4-aminophenyl)sulfonyl)amino-5-nitroimidazole
Metazoa
Antitrichomonal Agents
Drug Resistance
Bayer 5360
Nitroimidazoles
Sulfonamides
Trichomonas vaginalis
Helminth Drug Sensitivity Tests
In Vitro [Publication Type]

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