PMID: 6406704Mar 1, 1983Paper

In vitro study of in line filtration of medications commonly administered to pediatric cancer patients

JPEN. Journal of Parenteral and Enteral Nutrition
C E EnnisD N Neff

Abstract

Intravenous administration of drugs commonly used in patients with acute nonlymphocytic leukemia was simulated using a .22 micrometers air-eliminating filter. Drug concentrations were measured pre- and postfiltration using standard pediatric drug doses and concentrations. The percentage of administered dose recovered in the postfilter sample for chemotherapy drugs was adriamycin, 92%; dactinomycin, 87%; cytarabine, 96%; and vincristine, 90%. For antibiotics, the per cent recovery was carbenicillin, 90%; cephalothin, 96%; and gentamicin, 38%. Gentamicin, and perhaps other drugs evaluated, should not be administered through a filter of the type used in this study.

References

Jan 1, 1979·Therapeutic Drug Monitoring·C B Walberg, S H Wan
May 26, 1972·Biochemical and Biophysical Research Communications·K E RubensteinE F Ullman
Oct 1, 1981·The Journal of Pediatrics·P RajchgotS M MacLeod

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Citations

May 3, 2014·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tsuneaki YamanouchiIsao Adachi
Jun 28, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Joanna GaschHolger Knoth
Nov 12, 2015·International Journal of Pharmaceutics·Benjamin Patrick Werner, Gerhard Winter
Mar 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·D Watson
Jun 1, 2017·Journal of Pharmaceutical Sciences·Ahmed Besheer
May 11, 2011·Chemotherapy·Ilaria BononiMauro Tognon
Dec 1, 1989·Journal of Clinical Pharmacy and Therapeutics·R F Stevens, K M Wilkins
Feb 1, 1985·Drug Intelligence & Clinical Pharmacy·J K ElenbaasR M Elenbaas

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