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In vitro study of interaction of 17β-hydroxysteroid dehydrogenase type 10 and cyclophilin D and its potential implications for Alzheimer's disease

Scientific Reports

Nov 13, 2019

Erika HemmerováJirí Homola

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Abstract

In early stages of Alzheimer's disease (AD), amyloid-β (Aβ) accumulates in neuronal mitochondria where it interacts with a number of biomolecules including 17beta-hydroxysteroide dehydrogenase 10 (17β-HSD10) and cyclophilin D (cypD). It has been hypothesized that 17β-HSD10 interacts wit...read more

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Alzheimer's Disease
Environment
Ions
Neurons
3 (or 17)-beta-hydroxysteroid dehydrogenase
Clusterin
Cyclophilin D
Potassium Ion
In Vitro Study
Binding (Molecular Function)
1
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In vitro study of interaction of 17β-hydroxysteroid dehydrogenase type 10 and cyclophilin D and its potential implications for Alzheimer's disease

Scientific Reports

Nov 13, 2019

Erika HemmerováJirí Homola

PMID: 31723183

DOI: 10.1038/s41598-019-53157-7

Abstract

In early stages of Alzheimer's disease (AD), amyloid-β (Aβ) accumulates in neuronal mitochondria where it interacts with a number of biomolecules including 17beta-hydroxysteroide dehydrogenase 10 (17β-HSD10) and cyclophilin D (cypD). It has been hypothesized that 17β-HSD10 interacts wit...read more

Mentioned in this Paper

Alzheimer's Disease
Environment
Ions
Neurons
3 (or 17)-beta-hydroxysteroid dehydrogenase
1

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