In vitro study of role of trace amount of Cu release from Cu-bearing stainless steel targeting for reduction of in-stent restenosis.

Journal of Materials Science. Materials in Medicine
Ling RenKe Yang

Abstract

A novel 316L type Cu-bearing stainless steel was developed in present work, aiming at reducing the occurrence of the in-stent restenosis after implantations of coronary stents, through trace amount of Cu release from surface of the steel in body fluid. It was found that there was a trace amount of Cu released from the Cu-bearing steel in a simulated body fluid, with no cytotoxicity. All the in vitro experimental results proved that this Cu-bearing steel could not only inhibit the proliferation of vascular smooth muscle cells, reducing the formation of thrombosis, which are the main reasons for happening of the in-stent restenosis, but also promote the proliferation of vascular endothelial cells needed for the revascularization, showing that this novel steel is prospective to be a new material for manufacturing coronary stents with function of reducing the in-stent restenosis.

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Citations

Aug 3, 2013·Journal of Biomedical Materials Research. Part a·Ruiqiang HangBin Tang
Nov 25, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ling RenKe Yang
Aug 6, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Erlin ZhangKe Yang
Feb 11, 2015·Journal of Materials Science. Materials in Medicine·Jinzhao LiKe Yang
Jan 14, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Sani Namik MuratFatih Oksuz
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Jialin NiuWenjiang Ding
Oct 7, 2017·Journal of Biomedical Materials Research. Part a·Shujing JinHongshan Zhong
Oct 27, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jing ZhaoKe Yang
Jun 21, 2019·Journal of Materials Science. Materials in Medicine·Rui LiuKe Yang
Nov 20, 2020·Bioactive Materials·Peng WangXun Qi
Feb 12, 2021·Frontiers in Bioengineering and Biotechnology·Daorong XuBin Yu
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Anqi ShiErlin Zhang
Jul 9, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Deniz Eren ErişenXiaolin Wang
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Bingbing WangYong Huang

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