In vitro study of the antioxidant and immunomodulatory activity of aqueous infusion of Bidens pilosa

Journal of Ethnopharmacology
Celia AbajoMaría Pilar Vinardell

Abstract

Bidens pilosa is an annual plant from tropical America with anti-inflammatory properties in hepatitis, laryngitis, headache and digestive disorders, among others. Its wide pharmacological applications can be attributed to its chemical composition, with inhibitory effects on pathogenic microorganisms and flavonoids, which show strong antioxidant capacities. We investigated the antioxidant activity of an aqueous infusion of Bidens pilosa by studying its protective effect on the hemolysis induced by an initiator of radicals such as 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH). The immunomodulatory activity of the infusion was tested using whole blood cells. Cytokine production increased in whole blood stimulated or not by lipopolysaccharides (LPSs). The infusion is also characterized by its capacity to protect erythrocytes from the phototoxic effect of chlorpromazine, which allows its use as a potential photoprotector. Finally, it did not show ocular irritation, as demonstrated by the effect on hemoglobin denaturation. This study supports the health benefits of the ingestion of the infusion.

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Citations

Jul 29, 2010·Journal of Ethnobiology and Ethnomedicine·Mainen J MoshiAnke Weisheit
Oct 23, 2013·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Li-Hong ZhuYing Pan
Mar 18, 2008·Journal of Ethnopharmacology·Maicon Roberto KviecinskiRozangela Curi Pedrosa
May 20, 2008·Journal of Ethnopharmacology·Ronaldo de Jesus CostaBerenice Quinzani Jordão
Nov 15, 2006·Journal of Ethnopharmacology·Yi-Ming ChiangLie-Fen Shyur
Feb 27, 2017·Journal of Inorganic Biochemistry·Lucas B BolzonMarilda D Assis
Nov 6, 2018·Drug and Chemical Toxicology·Cristiane Martinez Ruiz PegoraroMarcos Alberto Zocoler
Oct 4, 2014·International Journal of Immunopathology and Pharmacology·M AkramA Naveed
Jan 1, 2016·Journal of Pharmaceutical Investigation·Tran Dang Xuan, Tran Dang Khanh
Dec 10, 2019·Journal of Ethnopharmacology·S van Vuuren, L Frank

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