In vitro study on the influence of strontium-doped calcium polyphosphate on the angiogenesis-related behaviors of HUVECs

Journal of Materials Science. Materials in Medicine
Y W ChenC X Wan

Abstract

Angiogenesis is of great importance in bone tissue engineering, and has gained large attention in the past decade. Strontium-doped calcium polyphosphate (SCPP) is a novel biodegradable material which has been proved to be able to promote in vivo angiogenesis during bone regeneration. An in vitro culture system was developed in the present work to examine its influence on angiogenesis-related behaviors of human umbilical vein endothelial cells (HUVECs), including cell adhesion, spreading, proliferation and migration. The effects of microtopography, chemical property and the ingredients in the degradation fluid (DF) on cell behaviors were discussed. The results showed that cells attached and spread better on SCPP scaffold than on calcium polyphosphate (CPP), which might partially result from the less rough surface of SCPP scaffold and the less hydrogel formed on the surface. In addition, cell proliferation was significantly improved when treated with SCPP DF compared with the treatment with CPP DF. Statistical analysis indicated that Sr(2+) in SCPP DF might be the main reason for the improved cell proliferation. Moreover, cell migration, another important step during angiogenesis, was evidently stimulated by SCPP DF. The improved...Continue Reading

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Citations

Mar 10, 2009·Journal of Materials Science. Materials in Medicine·Meng TianXiaohua Zhang
Oct 30, 2009·Journal of Materials Science. Materials in Medicine·Saeed HesarakiDavood Sharifi
Feb 9, 2012·Journal of Materials Science. Materials in Medicine·Huixu XieLongjiang Li
Feb 23, 2013·Journal of Materials Science. Materials in Medicine·Zhipeng GuXixun Yu
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May 27, 2021·Advanced Healthcare Materials·Monika ŠalandováLidy E Fratila-Apachitei

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