In vitro supplementation with different tocopherol homologues can affect the function of immune cells in old mice

Free Radical Biology & Medicine
D WuS N Meydani

Abstract

Alpha-tocophorel (T) is the most common form of vitamin E inplasma and tissues. Alpha-T is also believed to be superior to its homologues beta-T, gamma-T, and delta-T in antioxidant activity. Biological activity of alpha-T has been intensively studied in a number of bodily systems. In contrast, the other homologues have received little attention beyond the evaluation of their relative antioxidant activity. We as well as others have previously shown that alpha-T can enhance cell- mediated immune function of aged animals and humans. Gamma-T is a principal form of vitamin E in the American diet and some cooking oils contain substantial amount of beta-T and delta-T. Thus it is of public health interest to compare their biological effects with than of alpha-t in various systems. In this study, we used an in vitro supplementation protocol to determine immunologic effects of these T homologues on murine splenocytes. The results showed that all four T homologues enhance both spontaneous and mitogen-stimulated lymphocyte proliferation (LP) and the maximal enhancement produced by them was of the same magnitude. The dose range to produce maximal enhancement varied with different homologues. The efficiency was in the order of beta-T approx...Continue Reading

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Citations

Jan 31, 2009·Aging Clinical and Experimental Research·Sheau C ChaiBahram H Arjmandi
Jan 5, 2002·Experimental Gerontology·Nadine DouziechTamàs Fulop
Apr 18, 2002·Free Radical Biology & Medicine·Alison A BeharkaSimin Nikbin Meydani
Sep 17, 2002·The Journal of Nutritional Biochemistry·Bahram ArjmandiSimin Meydani
Nov 3, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K P High
Feb 2, 2012·Journal of Nutritional Science and Vitaminology·Noriko YamaguchiKiwamu Yoshikawa
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Aug 16, 2014·International Wound Journal·Rachel Hobson
May 11, 2005·Immunological Reviews·Simin Nikbin MeydaniDayong Wu
Feb 24, 2007·Molecular Aspects of Medicine·Elke ReiterStephan Christen
Jul 1, 2006·Expert Review of Clinical Immunology·Sung Nim Han, Simin Nikbin Meydani
Mar 17, 2007·Free Radical Research·J García-de-la-AsunciónJ Viña
May 21, 2010·The Journal of Nutrition·Zhihong RenDayong Wu
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Dec 1, 2018·IUBMB Life·Erin Diane LewisDayong Wu
Aug 15, 2018·Advances in Nutrition·Simin Nikbin MeydaniDayong Wu
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Jul 1, 2004·Mutation Research·Karen A O'LearyGary Williamson
Dec 23, 2009·Archives of Biochemistry and Biophysics·Sung Nim HanAngelo Azzi

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