PMID: 9429250Jan 16, 1998Paper

In vitro susceptibilities of recent field isolates of Mycoplasma hyopneumoniae and Mycoplasma hyosynoviae to valnemulin (Econor), tiamulin and enrofloxacin and the in vitro development of resistance to certain antimicrobial agents in Mycoplasma hyopneumoniae

Research in Veterinary Science
P C HannanP H Ripley

Abstract

The in vitro activities of valnemulin (Econor) and two other antimicrobial agents were determined against recent field strains of Mycoplasma hyopneumoniae and Mycoplasma hyosynoviae using a broth microdilution method. Valnemulin showed exceptional activity against M hyopneumoniae (MIC90 0.0005 microgram ml-1) and M hyosynoviae (MIC range 0.0001 microgram ml-1 to 0.00025 microgram ml-1) field strains. Tiamulin was 100-fold less active (MIC90 0.05 microgram ml-1) and enrofloxacin 20-fold less active (MIC90 0.01 microgram ml-1) than valnemulin against M hyopneumoniae field isolates and 20-fold to 25-fold less active (MIC range 0.0025 microgram ml-1 to 0.005 microgram ml-1) and 400-fold to 500-fold less active (MIC range 0.05 microgram ml-1 to 0.1 microgram ml-1) respectively against M hyosynoviae field isolates. No significant resistance developed to valnemulin or tiamulin in the type strain of M hyopneumoniae (strain J) or in a recent field isolate (MEVT G23) exposed to 10 in vitro passages in broths containing these antibiotics. Only slight resistance to oxytetracycline was observed. High resistance to tylosin developed in both M hyopneumoniae strains within five to seven in vitro passages in tylosin-containing broth. Providing ...Continue Reading

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Citations

Oct 6, 2005·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Tim StakenborgFreddy Haesebrouck
Oct 27, 2004·Antimicrobial Agents and Chemotherapy·J ViccaF Haesebrouck
Mar 19, 2013·The Journal of Veterinary Medical Science·Pacharee ThongkamkoonKoshi Yamamoto
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Mar 5, 2015·Bioorganic & Medicinal Chemistry Letters·Ying-Jie DongZhi-Bin Xu
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Dec 23, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Gang QiuJiakui Li
May 4, 2018·Chemical Biology & Drug Design·Zhao-Sheng ZhangYou-Zhi Tang
Jul 7, 2018·Natural Product Reports·Olivia GoetheSeth B Herzon
Aug 5, 2017·Biological & Pharmaceutical Bulletin·Shuhua MuYue Zhang
Jan 24, 2020·BMC Genomics·Yael YairInna Lysnyansky
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Jun 20, 2020·The Veterinary Journal·Dominiek MaesAnne V Gautier-Bouchardon
Jul 14, 2018·Microbiology Spectrum·Anne V Gautier-Bouchardon

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