In Vitro Susceptibility of Berberine Combined with Antifungal Agents Against the Yeast Form of Talaromyces marneffei

Mycopathologia
Hong LuoGang Liang

Abstract

Talaromyces (Penicillium) marneffei can cause fatal disseminated infection in immunocompromised hosts. However, therapeutic strategies for the mycosis are limited. Reports of the other fungi suggest that berberine, a component of traditional herb, inhibitors interact with antifungal agents to improve the treatment outcomes. In the study, we evaluated the in vitro efficacy of berberine in combination with conventional antifungal agents against the pathogenic yeast form of T. marneffei. We demonstrate the synergistic effect of combination of berberine with fluconazole (52.38%), itraconazole (66.67%), voriconazole (71.43%), amphotericin B (71.43%) or caspofungin (52.38%) of T. marneffei strains, respectively. Time-kill curves confirmed the synergistic interaction, and no antagonistic was observed in all of the combinations. In conclusion, berberine could enhance the efficacy of conventional antifungal agents against the yeast form of T. marneffei in vitro. The results indicated berberine might have a potential role in combination therapy for talaromycosis.

References

Dec 1, 1990·The Journal of Prosthetic Dentistry·K NakamotoT Hamada
Jul 9, 1994·Lancet·K SupparatpinyoT Sirisanthana
Jun 1, 1997·Antimicrobial Agents and Chemotherapy·M E KlepserM A Pfaller
Mar 4, 2005·Biological & Pharmaceutical Bulletin·Yongmoon Han, Jue-Hee Lee
Sep 18, 2012·Mycopathologia·Yongxuan HuLiyan Xi
Sep 4, 2014·The American Journal of Chinese Medicine·Chunqiu ChenMartin Storr
Jul 13, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·GaoXiang ShiChangZhong Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.