In vitro susceptibility of clinical yeast isolates to fluconazole and terconazole

American Journal of Obstetrics and Gynecology
C R Cooper, M R McGinnis

Abstract

Fifty clinical yeast isolates, representing equally Candida albicans, Candida krusei, Candida parapsilosis, Candida tropicalis, and Torulopsis glabrata, were tested in vitro for their susceptibility to terconazole and fluconazole. The minimal inhibitory concentrations of terconazole and fluconazole were determined by use of a proposed standardized broth macrodilution assay. Also, the response of selected yeast isolates to 25 micrograms of either drug was measured by agarose disk diffusion experiments. For all species the minimum inhibitory concentrations for terconazole were significantly lower than those for fluconazole (p < 0.05). In fact, for each individual isolate the minimum inhibitory concentration of terconazole was consistently lower than that of fluconazole. Differences in the geometric mean of terconazole and fluconazole minimum inhibitory concentrations were largest among C. krusei and T. glabrata, followed by C. parapsilosis, C. tropicalis, and C. albicans, in order of decreasing difference. Disk diffusion experiments suggested that terconazole is a more effective fungistatic agent than fluconazole is. Terconazole may be more effective than fluconazole against yeast species other than C. albicans.

References

Sep 1, 1992·Antimicrobial Agents and Chemotherapy·M A PfallerD W Warnock
Mar 1, 1992·Journal of Clinical Pharmacology·B J HorowitzS Ito
Oct 1, 1991·American Journal of Obstetrics and Gynecology·H Vanden Bossche, P Marichal
Jun 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Apr 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S E ReefR W Pinner
Jan 1, 1994·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·M E Lynch, J D Sobel
Dec 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D J BokenM G Rinaldi

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