In vitro susceptibility of Gardnerella vaginalis and Bacteroides organisms, associated with nonspecific vaginitis, to sulfonamide preparations.

Antimicrobial Agents and Chemotherapy
B M JonesI Geary

Abstract

Recent reports suggest that anaerobic Bacteroides organisms are frequently found with Gardnerella vaginalis in nonspecific vaginitis. Specimens taken from 96 women with vaginal discharge were tested simultaneously for these organisms. G. vaginalis was found in 73% of the specimens, Bacteroides was found in 53%, and both organisms were found in 47%. Sulfonamides have been widely used in the successful treatment of vaginitis. Paradoxically, G. vaginalis is reported to be resistant, and it has been suggested that it could be the vehicle of the drugs which effects the cure. Little is known of the susceptibility of vaginal anaerobes to the sulfonamides. G. vaginalis and Bacteroides isolates were therefore tested in vitro against the individual excipients of sulfonamide tablets, and minimal inhibitory concentration tests were also performed against the three active drugs. The excipients had no effect on G. vaginalis, but Bacteroides strains were susceptible to the urea component. All strains of both organisms were susceptible to at least two of the three sulfonamides at high concentrations.

References

Jun 29, 1978·The New England Journal of Medicine·T A PheiferK K Holmes
Aug 1, 1979·Antimicrobial Agents and Chemotherapy·L R McCarthyE G Smith
Jan 1, 1969·Antonie van Leeuwenhoek·W E Dunkelberg, I McVeigh
Sep 11, 1980·The New England Journal of Medicine·C A SpiegelK K Holmes
Apr 1, 1981·Antimicrobial Agents and Chemotherapy·B M Jones, M N Bhattacharyya

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Citations

Oct 1, 1982·European Journal of Clinical Microbiology·B M JonesB I Duerden
May 15, 1998·Journal of Nurse-midwifery·D M PaigeJ Chang
Aug 1, 1983·The British Journal of Venereal Diseases·A N MasfariB I Duerden
Aug 1, 1986·Genitourinary Medicine·A N MasfariG R Kinghorn

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