PMID: 9532262Apr 9, 1998Paper

In-vitro susceptibility of group A beta-haemolytic streptococci (GABHS) to penicillin, erythromycin, clarithromycin and azithromycin in Styria, Austria

Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology
I KrieberneggE Marth

Abstract

248 Strains of group A beta-haemolytic streptococci (GABHS) were tested against penicillin and the macrolide antibiotics, erythromycin, clarithromycin and azithromycin. 213 (85.9%) GABHS isolates were taken from throat swabs from patients with pharyngotonsillitis, 35 isolates (14.1%) were from other body sites or from invasive infections. The age of the patients ranged from 9 months to 89 years, 155 of the patients (62.5%) were below 10 years of age. The results of the E-test method and a disk diffusion assay were compared; to classify the phenotype of the erythromycin-resistant strains, a disk induction test was carried out. None of the 248 GABHS strains showed resistance to penicillin, whereas 53 GABHS isolates (21.4%) were resistant to the macrolide antibiotics included in the test. There were only minor discrepancies between the two testing methods. The MIC data obtained with the E-test method suggested that among the macrolides, erythromycin and clarithromycin had slightly higher antistreptococcal activity than azithromycin in vitro. 50 (94.3%) of the erythromycin-resistant GABHS showed the pattern of novel resistance (M phenotype), 2 (3.8%) strains showed inducible resistance (IR) and 1 (1.9%) strain exhibited consecutive...Continue Reading

References

Nov 1, 1979·American Journal of Diseases of Children·S MaruyamaY Satake
Jan 30, 1992·The New England Journal of Medicine·H SeppäläT Klaukka
Feb 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E L Kaplan
Dec 1, 1993·The Journal of Antimicrobial Chemotherapy·H SeppäläP Huovinen

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Citations

Apr 23, 1999·Diagnostic Microbiology and Infectious Disease·C BetriuJ J Picazo
Apr 30, 1999·Emerging Infectious Diseases·E Perez-TralleroM de Pablos
Nov 24, 1999·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·J Melo-Cristino, M L Fernandes
Jul 10, 2001·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·C M BrandtR R Reinert
Dec 6, 2001·The Pediatric Infectious Disease Journal·G A SyrogiannopoulosN G Beratis

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