PMID: 11337185May 5, 2001Paper

In vitro susceptibility of recent clinical isolates of Chlamydia trachomatis to macrolides and tetracyclines

Diagnostic Microbiology and Infectious Disease
Z SamraM Dan

Abstract

We tested the in vitro activity of clarithromycin, azithromycin, roxithromycin, erythromycin, doxycycline, and tetracycline against 50 clinical isolates of Chlamydia trachomatis. The minimal inhibitory concentrations (MICs) and the minimal bactericidal concentrations (MBCs) were determined in a tissue culture system using cycloheximide treated McCoy cells. MIC values for all the isolates were < or =0.015 microg/ml for clarithromycin, < or =0.125 microg/ml for roxithromycin and azithromycin, and < or =0.25 microg/ml for erythromycin and doxycycline. Almost half of the isolates (44%) were inhibited only by a concentration of 0.5 microg/ml of tetracycline. MBC as high as 4 microg/ml was displayed by doxycycline and tetracycline against 8% and 4% of the isolates respectively of the agents recommended by the Center for Disease Control as drugs of choice for the treatment of chlamydial infections, azithromycin exhibited a markedly better in-vitro activity than did erythromycin and doxycycline.

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Citations

Apr 1, 2009·Antimicrobial Agents and Chemotherapy·Geneviève Goy, Gilbert Greub
Jan 13, 2005·Gynäkologisch-geburtshilfliche Rundschau·Christian Ruef
Aug 26, 2014·Microbes and Infection·Marie de BarsyGilbert Greub
Nov 19, 2015·Journal of Microbiological Methods·Ildikó EszikDezső P Virok
Sep 16, 2015·Microbes and Infection·Vanissa A OngWilhelmina M Huston
Feb 12, 2004·Andrologia·G F GonzalesE Bustos-Obregón
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Oct 13, 2005·Expert Opinion on Pharmacotherapy·Laurence SennGilbert Greub
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Jan 13, 2015·Expert Opinion on Pharmacotherapy·Stephan A Kohlhoff, Margaret R Hammerschlag
Nov 7, 2013·Expert Review of Anti-infective Therapy·R Matthew ChicoDaniel Chandramohan
Oct 10, 2020·Expert Review of Anti-infective Therapy·Margaret R Hammerschlag, Roopali Sharma
Dec 11, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·Secondo Guaschino, Giuseppe Ricci

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