In vitro susceptibility-testing in Aspergillus species

Mycoses
C Lass-Flörl, Susanne Perkhofer

Abstract

Aspergillus species are the most common causes of invasive mould infections in immunocompromised patients. The introduction of new antifungal agents and recent reports of resistance emerging during treatment of Aspergillus infections have highlighted the need for in vitro susceptibility-testing. Various testing procedures have been proposed, including macrodilution and microdilution, agar diffusion, disc diffusion and Etest. At present, one of the most widely used assays is the M38-A reference method for filamentous fungi, published by the Clinical Laboratory Standard Institute and the Etest. Recently, the European Committee on Antimicrobial Susceptibility-testing (EUCAST) has charged its Antifungal Susceptibility-testing Subcommittee (AFST-EUCAST) with the preparation of new guidelines for in vitro susceptibility-testing of antifungals against Aspergillus spp. (EUCAST-AFST-ASPERGILLUS) defining breakpoints. This paper reviews the available methods for antifungal susceptibility-testing in Aspergillus spp. as well as the scant data regarding the clinical implications of in vitro testing.

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Citations

Nov 2, 2012·Antimicrobial Agents and Chemotherapy·Susanne PerkhoferCornelia Lass-Flörl
Sep 30, 2008·Applied and Environmental Microbiology·Matthias BrockOumaïma Ibrahim-Granet
May 6, 2010·Future Microbiology·Cornelia Lass-Flörl
May 17, 2012·Medical Mycology·Inès HadrichStéphane Ranque
May 17, 2014·Environmental Monitoring and Assessment·Magali LagoEugénia Pinto
Nov 3, 2009·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Paul E VerweijDavid W Denning
May 17, 2015·Medical Mycology·Marta SanchisJosep Guarro
Jan 1, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C Lass-Flörl
Jan 27, 2018·Biomédica : revista del Instituto Nacional de Salud·Javier L San JuanMaría T Illnait
Feb 14, 2012·Mycopathologia·Inès HadrichAli Ayadi

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