PMID: 9449166Jan 1, 1997Paper

In vitro susceptibility testing of Malassezia furfur against rilopirox

Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
P Nenoff, U F Haustein

Abstract

The in vitro antifungal activity of the new hydroxypyridone antimycotic rilopirox has been evaluated against 29 separate clinical isolates of Malassezia (M.) furfur obtained from patients with pityriasis versicolor, seborrhoeic dermatitis or dandruff. Minimum inhibitory concentrations (MICs) of rilopirox were measured by the agar dilution technique and, in comparison, by a recently described microdilution method with colorimetric detection of the MIC end points. Rilopirox was found to be able to inhibit growth of all clinical yeast isolates. For the investigated M. furfur strains MIC values from 12.5 to 50 micrograms ml-1 with a median of 25 micrograms ml-1 were determined by the agar dilution method. Using the microdilution technique, MIC values between 16 and 128 micrograms ml-1 (median 32 micrograms ml-1) were found for the M furfur isolates. It has to be taken into account that with a 0.3% solution concentrations of 300,000 micrograms ml-1 are applied to the skin. Furthermore, due to its extreme low penetration rilopirox is long-term available in the skin in inhibiting concentrations. In comparison with rilopirox, the in vitro susceptibility of M. furfur against the systemically applicable triazole antimycotic itraconazole ...Continue Reading

Citations

Jan 30, 2014·Anais Brasileiros De Dermatologia·Maria Fernanda Reis Gavazzoni DiasDavid Rubem Azulay
Mar 15, 2002·American Journal of Clinical Dermatology·Adam I RubinRichard K Scher

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