PMID: 7012631Jan 30, 1981Paper

In vitro susceptibility to 5-fluorocytosine and nystatin of common clinical yeast isolates

Mycopathologia
G NobreA F Ferreira

Abstract

The sensitivity to nystatin, 5-fluorocytosine (5-FC) or both was studied for 131 clinical isolates of Candida albicans, 47 of Candida parapsilosis, 34 of Candida tropicalis, 7 of Candida guilliermondii, 28 of Torulopsis glabrata and 1 of Torulopsis candida. All strains were inhibited by concentrations of nystatin within the usual range of sensitivity except one strain of T. glabrata and another of T. candida whose minima inhibitory concentrations (MICs) were respectively 250 U/ml and greater than 20000 U/ml. In respect to 5-FC it was found, after 7 days of incubation at 37 degrees C, the following frequencies of resistance: C. albicans 28/106 (26%), C. parapsilosis 11/47 (23%), C. tropicalis 24/34 (71%), C. guilliermondii 1/7, T. glabrata 1/28 (4%) and T. candida 0/1. It was particularly striking the activity of 5-FC against T. glabrata.

References

Jun 1, 1979·Journal of Clinical Microbiology·W G Merz, G R Sandford
Oct 1, 1978·Antimicrobial Agents and Chemotherapy·M A Saubolle, P D Hoeprich
Jan 1, 1974·Archives of Microbiology·D Sternberg, A S Sussman
Sep 1, 1973·Antimicrobial Agents and Chemotherapy·S Normark, J Schönebeck
Oct 1, 1974·Australian and New Zealand Journal of Medicine·F C Firkin
Nov 1, 1971·Journal of Medical Microbiology·M A Athar, H I Winner

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