In vitro thrombotic tendency of reactive thrombocytosis in critically ill patients: a prospective case-control study

Anaesthesia and Intensive Care
O DuffS M Maybury

Abstract

It is uncertain whether reactive thrombocytosis is associated with an increased risk of thrombosis. This prospective case-control study assessed the in vitro thrombotic tendency of patients with reactive thrombocytosis. Forty-eight patients with reactive thrombocytosis, defined by platelet count >500x10(9)/l and 55 similar, randomly selected critically ill patients who did not have reactive thrombocytosis were considered. In vitro thrombotic tendency in both groups of patients was assessed using maximal amplitude (normal range 54 to 72 mm) and alpha angle (normal range 47 to 74°) on the thromboelastograph. The associations between reactive thrombocytosis and C-reactive protein, the coagulation profile and Sequential Organ Failure Assessment score were also evaluated. Patients with reactive thrombocytosis had an associated increased in vitro thrombotic tendency (maximal amplitude 77 vs 69 mm, mean difference 8 mm, 95% confidence interval 4.9 to 10.9, P=0.001), a higher fibrinogen concentration (7.2 vs 5.8 g/l, P=0.003), and a higher incidence of infection requiring antibiotics (50 vs 27%, P=0.025) compared to patients without thrombocytosis. Platelet count had a relatively linear relationship with the maximal amplitude and the a...Continue Reading

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Citations

Apr 10, 2015·Journal of the American Society of Nephrology : JASN·Bryce A KerlinWilliam E Smoyer
Dec 15, 2017·European Journal of Haematology·Amihai RottenstreichYosef Kalish
Jul 13, 2012·Journal of Thrombosis and Haemostasis : JTH·K M HoO Duff
Sep 30, 2016·Wiener medizinische Wochenschrift·Rayko Evstatiev
Jun 29, 2021·International Journal of General Medicine·Scarlett TohmeNisha Lakhi

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