Abstract
It is uncertain whether reactive thrombocytosis is associated with an increased risk of thrombosis. This prospective case-control study assessed the in vitro thrombotic tendency of patients with reactive thrombocytosis. Forty-eight patients with reactive thrombocytosis, defined by platelet count >500x10(9)/l and 55 similar, randomly selected critically ill patients who did not have reactive thrombocytosis were considered. In vitro thrombotic tendency in both groups of patients was assessed using maximal amplitude (normal range 54 to 72 mm) and alpha angle (normal range 47 to 74°) on the thromboelastograph. The associations between reactive thrombocytosis and C-reactive protein, the coagulation profile and Sequential Organ Failure Assessment score were also evaluated. Patients with reactive thrombocytosis had an associated increased in vitro thrombotic tendency (maximal amplitude 77 vs 69 mm, mean difference 8 mm, 95% confidence interval 4.9 to 10.9, P=0.001), a higher fibrinogen concentration (7.2 vs 5.8 g/l, P=0.003), and a higher incidence of infection requiring antibiotics (50 vs 27%, P=0.025) compared to patients without thrombocytosis. Platelet count had a relatively linear relationship with the maximal amplitude and the a...Continue Reading
References
Mar 1, 1994·The American Journal of Medicine·D H BussL D Case
Apr 17, 1999·Journal of Internal Medicine·M GriesshammerH Heimpel
Jan 27, 2000·Annals of Hematology·M BazzanA Pileri
Jan 17, 2002·Blood Reviews·A I Schafer
Mar 19, 2004·The New England Journal of Medicine·Andrew I Schafer
Jun 10, 2004·The Journal of Trauma·David J SchultzJohn Weigelt
Oct 16, 2004·British Journal of Anaesthesia·N ValadeF Stéphan
Nov 21, 2007·Anaesthesia and Intensive Care·K M Ho
Apr 30, 2009·Anaesthesia and Intensive Care·K M Ho, J Lipman
May 12, 2009·The Journal of Trauma·Ali SalimDaniel R Margulies
Aug 12, 2009·The Journal of Trauma·Myung S ParkJohn B Holcomb
Jan 30, 2010·Critical Care Medicine·Deborah J Cook, Mark A Crowther
Aug 20, 2010·Surgery·Jeffry L KashukAngela Sauaia
Sep 24, 2010·British Journal of Anaesthesia·K M HoR Baker
Sep 24, 2011·Chest·Kwok M HoDavid Pilcher
Oct 6, 2011·Anaesthesia and Intensive Care·N M Gibbs
Citations
Dec 18, 2015·Anaesthesia and Intensive Care·Y Harahsheh, K M Ho
Jul 21, 2012·Anaesthesia and Intensive Care·K M Ho
Apr 10, 2015·Journal of the American Society of Nephrology : JASN·Bryce A KerlinWilliam E Smoyer
Dec 15, 2017·European Journal of Haematology·Amihai RottenstreichYosef Kalish
Jul 13, 2012·Journal of Thrombosis and Haemostasis : JTH·K M HoO Duff
Jan 30, 2014·Anaesthesia and Intensive Care·K M Ho, D J Morgan
Jan 6, 2016·Transfusion Medicine·K M Ho, C B Yip
Sep 30, 2016·Wiener medizinische Wochenschrift·Rayko Evstatiev
May 7, 2015·Anaesthesia and Intensive Care·K M Ho, O C Duff
Dec 15, 2012·Thrombosis and Haemostasis·Kwok M Ho, Shaila Chavan
May 7, 2021·Journal of Clinical Laboratory Analysis·Chuanzeng RenRongge Cao
Jun 29, 2021·International Journal of General Medicine·Scarlett TohmeNisha Lakhi