PMID: 11311449Apr 20, 2001Paper

In vitro tolerance to inhibition by ethanol of N-methyl-D-aspartate-induced depolarization in locus coeruleus neurons of behaviorally ethanol-tolerant rats

Neurochemistry International
W PoelchenP Illes

Abstract

Intracellular recordings were made in pontine slice preparations of the rat brain containing the locus coeruleus (LC). Ethanol at 100 mM, but not at 10 or 30 mM inhibited depolarizing responses to pressure-applied N-methyl-D-aspartate (NMDA) in LC neurons of ethanol-naive rats. Ethanol (100 mM) had a similar effect in LC neurons of ethanol-naive rats, of rats treated with ethanol for 14 days (3 g/kg daily, i.p.) and of rats treated with equicaloric amounts of saccharose (5 g/kg daily, i.p.). The blood concentration of ethanol was markedly decreased at 4 h, and was below the detection limit at 24 h after the last injection. Behavioral measurements in the open-field system demonstrated the development of tolerance in rats receiving ethanol for 14 days. Moreover, an anxiety-related reaction was shown to develop when the acute effect of the last ethanol injection vanished. Therefore, in subsequent in vitro experiments, ethanol (10 mM) was continuously present in the superfusion medium in order to mimic a steady blood concentration and to prevent a withdrawal-like situation. Under these conditions, ethanol (100 mM) still continued to inhibit the NMDA-induced depolarization in slices of untreated rats, but became ineffective in slice...Continue Reading

References

Feb 1, 1992·Naunyn-Schmiedeberg's Archives of Pharmacology·G Engberg, M Hajós
Oct 1, 1992·Naunyn-Schmiedeberg's Archives of Pharmacology·G Engberg, M Hajós
Jul 1, 1985·The Journal of Physiology·R A North, J T Williams
Dec 1, 1988·The Journal of Physiology·E CherubiniJ T Williams
Feb 1, 1974·European Journal of Pharmacology·J KorfG K Aghajanian
Jul 22, 1983·European Journal of Pharmacology·R AndradeG K Aghajanian
May 1, 1996·Neuron·B Tabakoff, P L Hoffman
Jan 1, 1996·Annual Review of Pharmacology and Toxicology·R W PeoplesF F Weight
Sep 26, 1997·Naunyn-Schmiedeberg's Archives of Pharmacology·D M Lovinger
Feb 12, 1998·British Journal of Pharmacology·T IbbotsonP R Boden
Mar 24, 1998·Annual Review of Medicine·G Tsai, J T Coyle
Apr 29, 1998·Naunyn-Schmiedeberg's Archives of Pharmacology·K NieberP Illes
Feb 3, 1999·Journal of Neural Transmission·W Fischer, H Kittner
Jul 16, 1999·Neurochemistry International·J J Woodward
Jul 16, 1999·Neurochemistry International·K WirknerP Illes
Oct 21, 1999·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·P RiihiojaA Hervonen

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Citations

Sep 6, 2002·Neurochemistry International·C Allgaier
Feb 28, 2003·Neurochemistry International·József NagyLászló Fodor
May 3, 2003·Brain Research Bulletin·John G McCoyChristopher P Ward
Jan 12, 2005·Neuroscience and Biobehavioral Reviews·Christopher L Kliethermes
Aug 30, 2008·Critical Reviews in Food Science and Nutrition·Jonathan Mosqueda-MelgarOlga Martín-Belloso

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