In Vitro toxicity of 2- and 4-chloroaniline: comparisons with 4-amino-3-chlorophenol, 2-amino-5-chlorophenol and aminophenols

Toxicology in Vitro : an International Journal Published in Association with BIBRA
M A ValentovicG O Rankin

Abstract

Chloroanilines have been associated with renal and hepatic toxicity. This study (a) examined the in vitro hepatic and renal toxicity of 2-chloroaniline and 4-chloroaniline, (b) further examined whether aromatic ring hydroxylation would increase toxicity of the parent compound and (c) compared toxicity between respective aminochlorophenol and aminophenol. Renal and hepatic slices were exposed to varying concentrations of 2-chloroaniline, 4-chloroaniline. 4-amino-3-chlorophenol, 2-amino-5-chlorophenol, 2-aminophenol or 4-aminophenol. Toxicity was monitored by measurement of pyruvate-directed gluconeogenesis and leakage of lactate dehydrogenase (LDH). Hepatic tissue was less susceptible to toxicity than kidney tissue for all compounds since LDH leakage was elevated only in renal tissue. Gluconeogenesis was reduced in renal cortical slices exposed to 0.1 mum aminochlorophenols or 4-aminophenol, whereas a concentration of 0.5 mum was necessary for the chloroanilines and 2-aminophenol. LDH release was increased in renal slices by aminochlorophenols and aminophenols but not by the chloroanilines. The nephrotoxic potential in renal cortical slices was 4-aminophenol > 2-amino-5-chlorophenol > 4-amino-3-chlorophenol > 2-aminophenol > 2-c...Continue Reading

References

Jan 1, 1992·Renal Failure·I KondouH Endou
Nov 1, 1992·Toxicology·M A ValentovicG O Rankin
Jul 1, 1991·European Journal of Drug Metabolism and Pharmacokinetics·G CocchiaraM Strolin Benedetti
Jan 1, 1989·Archives of Toxicology·K P GartlandJ K Nicholson
Jan 1, 1988·The International Journal of Biochemistry·L Garcia-Salguero, J A Lupiañez
Jul 1, 1969·The Journal of Pharmacy and Pharmacology·S McLeanJ Thomas
Aug 1, 1984·Kidney International·W G Guder, B D Ross
Jan 1, 1980·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·R D Kimbrough
Sep 15, 1982·Toxicology and Applied Pharmacology·J F NewtonJ B Hook
Jul 1, 1995·Journal of Toxicology and Environmental Health·K A BlackS W Frantz
Mar 1, 1995·Journal of Applied Toxicology : JAT·G O RankinJ L Hubbard

❮ Previous
Next ❯

Citations

Dec 25, 2002·Toxicology·Jennifer L Minigh, Monica A Valentovic
Apr 8, 2003·Toxicology·Jennifer L Minigh, Monica A Valentovic
Dec 3, 2014·Chemico-biological Interactions·Gary O RankinDianne K Anestis
May 23, 2014·Acta Odontologica Scandinavica·Samuel Henrique Câmara De BemJesus Djalma Pécora
Nov 19, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Monica A ValentovicTierra Williams
Jan 10, 2002·Biochimica Et Biophysica Acta·Emanuele ArgeseFrancesca Agnoli
Jul 21, 2006·The Journal of Physical Chemistry. B·Manuel A V Ribeiro da SilvaAna I M C L Ferreira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.