PMID: 9426370Jan 14, 1998Paper

In vitro toxicity of trichothecenes on human erythroblastic progenitors

Human & Experimental Toxicology
B RioD Parent-Massin

Abstract

Trichothecenes are mycotoxins produced by various species of fungi which can occur on various agricultural products. Among these compounds, T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS) and deoxynivalenol (DON) are the most naturally encountered and potent trichothecenes. Consumption of trichothecene contaminated foods by farm animals and humans leads to mycotoxicoses. Trichothecenes are known to induce haematologic disorders such as neutropenia, thrombopenia, and aplastic anemia in human and animals. The aim of our investigations is to explore the effects of trichothecenes on the haematopoietic progenitors. The four trichothecenes previously demonstrated to be strongly cytotoxic for human CFU-GM have been tested on human BFU-E. For this purpose, a culture model of human erythroblastic progenitors (BFU-E) optimized for toxicological studies was used to determine the effects of T-2, HT-2, diacetoxyscirpenol (DAS) and deoxynivalenol (DON) on red blood cell precursor proliferation and differentiation. Results showed that human BFU-E are as sensitive to trichothecenes as human CFU-GM, except for DON, in the range of concentrations tested. Differentiation of erythroblastic progenitors could be perturbed by these mycotoxins. Human ...Continue Reading

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Citations

May 17, 2006·Cell Biology and Toxicology·N HymeryD Parent-Massin
May 24, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·G Le DréanD Parent-Massin
May 18, 2000·Toxicology·F ShokriM Ghazi-Khansari
Sep 25, 2001·Toxicology·H S Hussein, J M Brasel
May 17, 2003·Toxicology Letters·Daniel L Sudakin
Nov 8, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R FroquetD Parent-Massin
Aug 6, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·András SzabóMelinda Kovács
Feb 14, 2015·Drug and Chemical Toxicology·Navneet Kumar YadavR K Singh
Oct 19, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Sumanta ChatterjeeSujata Law
Nov 4, 2009·Toxicology·D Parent-MassinY Sibiril
May 16, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·N HymeryD Parent-Massin
Jul 8, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C CroeraL Gribaldo
Sep 3, 2004·Toxicology Letters·D Parent-Massin
Mar 7, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·N HymeryD Parent-Massin
Aug 28, 2012·Toxicon : Official Journal of the International Society on Toxinology·A S FicheuxD Parent-Massin
Nov 29, 2011·Toxicon : Official Journal of the International Society on Toxinology·A S FicheuxD Parent-Massin
Jan 10, 2013·Toxicology and Industrial Health·Mehmet GürbüzelHalit Kizilet
May 1, 2001·Human & Experimental Toxicology·R FroquetD Parent-Massin
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Sep 11, 2017·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Lutz Edler
Aug 16, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Lutz Edler
Sep 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Arnau VidalMarthe De Boevre

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