PMID: 4289741Apr 1, 1967Paper

In vitro transformation by the adenovirus-SV40 hybrid viruses. II. Characteristics of the transformation of hamster cells by the adeno 2-, adeno 3-, and adeno 12-SV40 viruses

The Journal of Experimental Medicine
P H Black, B J White

Abstract

Primary weanling hamster kidney cultures were transformed with the adeno 2-SV40, adeno 3-SV40, and adeno 12-SV40 hybrid viruses and with adenovirus type 12. The transformed cell lines which were established were characterized with respect to morphology, virus and antigen content, and chromosome aberrations. The adeno 2 and adeno 3-SV40 hybrid transformed cells had the morphology and T antigen content characteristic of SV40 transformations; cells transformed by the former hybrid had cytogenetic changes typical of SV40-transformed cells as well. The adeno 12-SV40 transformed cells were similar morphologically to adeno 12-transformed cells, contained both the SV40 and adeno T antigens and demonstrated the karyotypic instability of SV40-transformed cells, indicating that both viral genomes are operative in these cells. Although the results indicate that the SV40 genome in hybrids derived from the moderately or nononcogenic adenoviruses supplies the determinants for most of the characteristics investigated, and perhaps for oncogenesis, evidence was presented which suggests that a portion of a nononcogenic adenovirus genome may be integrated in adeno 2-SV40 transformed cells and directs the synthesis of adenovirus T antigens.

References

Oct 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·K K Takemoto, K Habel
Nov 1, 1965·The Journal of Experimental Medicine·W P RoweM D Hoggan
Sep 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·W P Rowe
Aug 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·P H Black, G J Todaro
Sep 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·F RappJ L Melnick
Feb 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·P R ReichS M Weissman
Mar 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·A M LewisW P Rowe
May 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·A M LewisW P Rowe
May 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·W P Rowe, W E Pugh
Nov 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·S G BaumS M Weissman
Aug 1, 1963·Journal of Cellular Physiology·P S MOORHEAD, E SAKSELA
Aug 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·R J HUEBNERW T LANE
Oct 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·P H BLACK, W P ROWE
Dec 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·P H BLACKR J HUEBNER
May 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·A S RABSONF J PAUL
Aug 1, 1964·The Journal of Experimental Medicine·J H POPE, W P ROWE
Oct 1, 1964·The Journal of Experimental Medicine·J H POPE, W P ROWE
Aug 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·A FJELDEE BRYAN
Dec 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·R J HUEBNERM J CASEY
Dec 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·W P ROWE, S G BAUM
Jan 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·M D HOGGANR J HUEBNER

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Citations

Jan 1, 1972·Archiv für die gesamte Virusforschung·S S LayneF Rapp
Mar 16, 1978·Nature·J M Clark, J A Pateman
May 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·P H BlackW P Rowe
Sep 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·A E FreemanR J Huebner
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J S RhimR J Huebner
Jan 15, 1970·International Journal of Cancer. Journal International Du Cancer·J M EastonR A Malmgren
Aug 1, 1973·Acta Pathologica Japonica·F Chino
Mar 15, 1969·International Journal of Cancer. Journal International Du Cancer·W H Burns, P H Black
Jan 15, 1971·International Journal of Cancer. Journal International Du Cancer·J S ButelS S Tevethia

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