In Vitro Weight-Loaded Cell Models for Understanding Mechanodependent Molecular Pathways Involved in Orthodontic Tooth Movement: A Systematic Review

Stem Cells International
Mila JanjicUwe Baumert

Abstract

Cells from the mesenchymal lineage in the dental area, including but not limited to PDL fibroblasts, osteoblasts, and dental stem cells, are exposed to mechanical stress in physiological (e.g., chewing) and nonphysiological/therapeutic (e.g., orthodontic tooth movement) situations. Close and complex interaction of these different cell types results in the physiological and nonphysiological adaptation of these tissues to mechanical stress. Currently, different in vitro loading models are used to investigate the effect of different types of mechanical loading on the stress adaptation of these cell types. We performed a systematic review according to the PRISMA guidelines to identify all studies in the field of dentistry with focus on mechanobiology using in vitro loading models applying uniaxial static compressive force. Only studies reporting on cells from the mesenchymal lineage were considered for inclusion. The results are summarized regarding gene expression in relation to force duration and magnitude, and the most significant signaling pathways they take part in are identified using protein-protein interaction networks.

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Citations

Mar 8, 2020·European Journal of Orthodontics·Damien BrezulierSylvie Jeanne
May 20, 2020·Scientific Reports·Yehuda KleinStella Chaushu
Nov 17, 2020·Advanced Healthcare Materials·Sanja AveicHorst Fischer
Jan 6, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Irma AzraqMichael Wolf
Sep 14, 2021·Frontiers in Bioengineering and Biotechnology·Changyun SunUwe Baumert

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Software Mentioned

Primer
PRISMA
BLAST
EndNote X8
STRING

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