In vivo β-adrenergic blockade by propranolol prevents isoproterenol-induced polycystic ovary in adult rats

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
S Leticia LunaHernán E Lara

Abstract

Increasing evidence in animal models and in humans shows that sympathetic nerve activity controls ovarian androgen biosynthesis and follicular development. Thus, sympathetic nerve activity participates in the follicular development and the hyperandrogenism characteristics of polycystic ovary syndrome, which is the most prevalent ovarian pathology in women during their reproductive years. In this study, we mimic sympathetic nerve activity in the rat via "in vivo" stimulation with isoproterenol (ISO), a β-adrenergic receptor agonist, and test for the development of the polycystic ovary condition. We also determine whether this effect can be reversed by the administration of propranolol (PROP), a β-adrenergic receptor antagonist. Rats were treated for 10 days with 125 μg/kg ISO or with ISO plus 5 mg/kg PROP. The ovaries were examined 1 day or 30 days following drug treatment. While ISO was present, the ovaries had an increased capacity to secrete androgens; ISO + PROP reversed this effect on androgen secretory activity. 30 days after treatment, androstenedione secretion reverted to normal levels, but an increase in the intra-ovarian nerve growth factor (NGF) concentration and luteinizing hormone (LH) plasma levels was detected. IS...Continue Reading

Citations

Oct 12, 2014·Current Hypertension Reports·Manuel Luque-Ramírez, Héctor F Escobar-Morreale
Nov 23, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Maritza P GarridoAlfonso H Paredes
Jul 22, 2014·Journal of Neuroendocrinology·D ToufexisV Viau
Sep 9, 2018·Reproductive Biology and Endocrinology : RB&E·Julieta A EspinozaLeticia Morales-Ledesma
Nov 21, 2019·Reproductive Biology and Endocrinology : RB&E·Berenice VenegasLeticia Morales-Ledesma

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