In vivo (123)I IBZM SPECT imaging of striatal dopamine 2 receptor occupancy in schizophrenic patients

Psychopharmacology
C BarnasS Kasper

Abstract

Single photon emission computed tomography (SPECT) using (123)I iodobenzamide (IBZM) as tracer substance has been shown to be a useful tool to visualize dopamine 2 (D2) receptor occupancy. We investigated the striatal D2 receptor occupancy of zotepine which is referred to the class of atypical antipsychotic drugs. (123)I IBZM and SPECT were used to visualize striatal dopamine 2 (D2) receptor occupancy in zotepine-treated schizophrenic patients. Two groups of schizophrenic patients receiving either 150 mg/day zotepine (n=6) or 300 mg/day (n=6) underwent examination. For the quantification of striatal D2 receptor occupancy, striatal IBZM binding in patients treated with antipsychotics was compared to untreated healthy controls (n=8) reported earlier. Zotepine led to a mean overall striatal D2 receptor occupancy of 73%. Patients with 150 mg daily showed a significantly lower occupancy (65.8%, SD=6.2) than patients with 300 mg/day (77.8%, SD=10.7; P<0.05). No clinically relevant extrapyramidal side effects occurred during treatment with zotepine. There was no correlation between the degree of striatal D2 receptor occupancy and clinical improvement.

Citations

Jan 16, 2004·Pharmacology, Biochemistry, and Behavior·Andrew J GoudieJon C Cole
Dec 7, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Peter S Talbot, Marc Laruelle
Feb 28, 2003·Seminars in Nuclear Medicine·Hank F KungSeok Rye Choi
Dec 14, 2002·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Siegfried KasperThomas Brücke
Nov 8, 2012·Journal of Clinical Psychopharmacology·Ching-Hua LinHsien-Yuan Lane

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