In vivo 13C-MRI using SAMBADENA

PloS One
Andreas Benjamin SchmidtJan-Bernd Hövener

Abstract

Magnetic Resonance Imaging (MRI) is a powerful imaging tool but suffers from a low sensitivity that severely limits its use for detecting metabolism in vivo. Hyperpolarization (HP) methods have demonstrated MRI signal enhancement by several orders of magnitude, enabling the detection of metabolism with a sensitivity that was hitherto inaccessible. While it holds great promise, HP is typically relatively slow (hours), expensive (million $, €) and requires a dedicated device ("polarizer"). Recently, we introduced a new method that creates HP tracers without an external polarizer but within the MR-system itself based on parahydrogen induced polarization (PHIP): Synthesis Amid the Magnet Bore Allows Dramatically Enhanced Nuclear Alignment (SAMBADENA). To date, this method is the simplest and least cost-intensive method for hyperpolarized 13C-MRI. HP of P13C > 20% was demonstrated for 5mM tracer solutions previously. Here, we present a setup and procedure that enabled the first in vivo application of SAMBADENA: Within seconds, a hyperpolarized angiography tracer was produced and injected into an adult mouse. Subsequently, fast 13C-MRI was acquired which exhibited the vena cava, aorta and femoral arteries of the rodent. This first SA...Continue Reading

References

Dec 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J HennigH Friedburg
Jan 1, 1967·Circulation Research·H Wolinsky, S Glagov
Jul 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K GolmanJ S Petersson
Apr 19, 2005·Magnetic Resonance Imaging·Maurice GoldmanMagnus Karlsson
Feb 17, 2007·Journal of Magnetic Resonance·Pratip BhattacharyaDaniel P Weitekamp
Apr 6, 2007·Journal of the American Chemical Society·Igor V KoptyugRenad Z Sagdeev
Mar 14, 2008·Journal of the American Chemical Society·Eduard Y ChekmenevDaniel P Weitekamp
Oct 10, 2008·Seminars in Neurology·Victor XuBrian D Ross
Dec 11, 2008·Magma·Jan-Bernd HövenerPratip Bhattacharya
Dec 11, 2008·Magma·Jan-Bernd HövenerPratip Bhattacharya
Mar 5, 2009·Journal of the American Chemical Society·Eduard Y ChekmenevPratip Bhattacharya
Mar 19, 2011·NMR in Biomedicine·Jan H Ardenkjaer-LarsenTimothy W Skloss
Dec 8, 2011·Journal of the American Chemical Society·Niki M ZachariasPratip Bhattacharya
Feb 23, 2012·Journal of the American Chemical Society·Roman V ShchepinEduard Y Chekmenev
Oct 30, 2012·Journal of Magnetic Resonance·Sébastien BärJan-Bernd Hövener
Aug 16, 2013·Science Translational Medicine·Sarah J NelsonJonathan A Murray
Jan 31, 2014·Journal of Magnetic Resonance Imaging : JMRI·Oliver KraffMark E Ladd
Jun 12, 2014·Stroke; a Journal of Cerebral Circulation·Kambiz NaelChelsea S Kidwell
Jul 6, 2014·Journal of Labelled Compounds & Radiopharmaceuticals·Roman V ShchepinEduard Y Chekmenev
Jul 22, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David Johannes ScholzMarion I Menzel
Jan 6, 2015·Nature Communications·Francesca ReineriSilvio Aime
Jan 8, 2015·Angewandte Chemie·Stefan GlögglerLouis-S Bouchard
May 13, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ana Beatriz SolanaFlorian Wiesinger
Nov 6, 2015·Journal of Magnetic Resonance·Matthew L HirschJames G Kempf
Nov 22, 2016·Chemistry : a European Journal·Eleonora CavallariFrancesca Reineri
Jan 17, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Axel J KrafftClaudia M Hillenbrand
May 12, 2017·Nature Communications·Stephan DüwelFranz Schilling
Jun 27, 2017·Journal of Invertebrate Pathology· Ab
Feb 16, 2018·Journal of Magnetic Resonance·Eleonora CavallariFrancesca Reineri

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Citations

Sep 20, 2019·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Kai BuckenmaierAndrey N Pravdivtsev
Aug 19, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jason Graham SkinnerJan-Bernd Hövener
Apr 6, 2019·Chemistry : a European Journal·Alexandra SvyatovaIgor V Koptyug
Sep 4, 2019·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Andreas B SchmidtJan-Bernd Hövener
Jan 7, 2020·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Neil J Stewart, Shingo Matsumoto
Jul 11, 2020·Catalysis Science & Technology·Ben J TicknerSimon B Duckett
Jan 16, 2021·Physical Chemistry Chemical Physics : PCCP·Stephan BernerJan-Bernd Hövener
Feb 17, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Neil J StewartShingo Matsumoto
Jun 26, 2021·Physical Chemistry Chemical Physics : PCCP·Andrey N PravdivtsevJan-Bernd Hövener
Aug 1, 2019·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Oleg G SalnikovEduard Y Chekmenev
Oct 9, 2018·The Journal of Physical Chemistry. a·Andrey N PravdivtsevJan-Bernd Hövener
Dec 5, 2019·Analytical Chemistry·Baptiste JoallandEduard Y Chekmenev
Oct 9, 2018·The Journal of Physical Chemistry. a·Andrey N PravdivtsevJan-Bernd Hövener
Dec 1, 2021·Physical Chemistry Chemical Physics : PCCP·Andreas B SchmidtAndrey N Pravdivtsev
Dec 8, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Andrey N PravdivtsevAndreas B Schmidt

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Methods Mentioned

BETA
genetic modifications

Software Mentioned

SAMBADENA
SAH
MATLAB
SABRE
PHIP
PASADENA

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