PMID: 9001142Feb 1, 1997Paper

In vivo 23Na NMR studies of myotonic dystrophy

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
T KushnirGil Navon

Abstract

Myotonic dystrophy is an inherited multi-system disease. Its pathophysiology leading to muscle malfunction and damage is not well understood. 23Na NMR spectroscopy was applied here for an in vivo comparative study of the calf muscles of 7 myotonic dystrophy patients at various stages of the disease and 11 healthy volunteers. Both the total sodium content, expressed as the ratio of the 23Na and 1H water signals, and the fast transverse relaxation time, T2f, determined from the triple quantum-filtered spectra, increased in correlation with the severity of the disease. The results demonstrate that 23Na NMR enables the quantitation of myotonic dystrophy progression.

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Citations

Jan 22, 2000·Molecular Aspects of Medicine·C Boesch
Jun 5, 2003·The Journal of Clinical Investigation·John R Forder, Gerald M Pohost
May 13, 2014·Progress in Nuclear Magnetic Resonance Spectroscopy·Guillaume MadelinAlexej Jerschow
Jun 16, 2006·Radiology·Marc-André WeberHans-Michael Meinck
Apr 17, 2013·Journal of Magnetic Resonance·Uzi EliavGil Navon
Dec 28, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sònia Nielles-VallespinLothar R Schad
Jan 30, 2007·Journal of Magnetic Resonance Imaging : JMRI·Chris Boesch
Jun 13, 2019·Topics in Magnetic Resonance Imaging : TMRI·Sebastian C NiesporekTanja Platt
Feb 17, 2015·NMR in Biomedicine·Paul A Bottomley
Jun 1, 2013·Journal of Magnetic Resonance Imaging : JMRI·Guillaume Madelin, Ravinder R Regatte
Feb 26, 2019·Frontiers in Neurology·Matteo PaolettiMassimiliano Filosto

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